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Effect of omeprazole, pantoprazole and famotidine on rat bones

Prof. hala abdel malek,  halamalek@live.com

Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, 35516, Mansoura, Egypt

Corresponding author 1

Abstract: Acid-suppressive drugs usage is widespread in osteoporotic patients. An association between gastric acid suppressants and increased any-site fractures risk has been found denoting the possible effects of chronic use of omeprazole, pantoprazole (PPIs) and famotidine (H₂ receptor antagonist). Forty eight (48) female Sprague–Dawley rats were used, they were divided into two main groups. group A. (7-week old), group B. (7-month old). Each main group was subdivided into four subgroups. omeprazole, pantoprazole, famotidine treated and received drugs orally/ day (successive 3 months), and control. Then, blood was collected for serum calcium, alkaline phosphatase, estradiol, and osteocalcin levels. Femurs were processed for histopathology. Omeprazole or pantoprazole administration produced bone loss (low serum calcium, elevated alkaline phosphatase, and osteocalcin and decrease in cortical and trabecular bone thickness). These drugs have no effect on serum estradiol level. The effects of these drugs on bone tissue were more prominent in old rats. On the other hand, famotidine produced bone changes only in old rats. It could be concluded, omeprazole or pantoprazole induces bone lesions which are more prominent in old age. Famotidine affects only old age. This is may be due to calcium deficiency resulted from prolonged gastric acid suppression.

[prof. hala abdel malek, Effect of omeprazole, pantoprazole and famotidine on rat bones. Life Sci J 2024;21(1):1-17]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 01. doi:10.7537/marslsj210124.01.

Keywords. acid-suppressive drugs, H₂ receptor antagonists (H₂RA), proton pump inhibitors (PPIs), osteoporosis.

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Chemical Constituents and Biological Activity of Forsskaolea viridis Aerial parts

Fatma A. Ahmed¹, Amani M.D. El mesallamy², Taha A.I. El Bassossy^1*

¹Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt

²Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

*Corresponding Author: tahachemist2008@gmail.com

Abstract: Chemical investigation of the chloroform and ethyl acetate extracts of the aerial parts of Forsskaolea viridis Ehrenb. ex Webb (Family: Urticaceae) led to isolation of eight compounds, for the first time, from this plant. Two phenolics and six flavonoid compounds were identified as p-coumaric and caffeic acids, 5-hydroxy-6,7,3',4'-tetramethoxy flavone, chrysoeriol, acacetin, chrysoeriol-7-O-β-D-glucopyranoside, kaempferol-3-O-(2"-O-E--p-coumaroyl)-β-D-glucopyranoside and isovetixin. The chemical structure of the isolated compounds was established by spectroscopic analysis UV, ¹H-NMR,¹³C-NMR and MS. The antimicrobial, antioxidant and cytotoxic activities of the ethyl acetate and chloroform extracts were evaluated. The ethyl acetate extract exhibited strong antimicrobial activity (12-30 mm) against the tested strains. The ethyl acetate and chloroform extracts showed fair antioxidant and cytotoxicity.

[Fatma A. Ahmed, Amani M.D. El mesallamy, Taha A.I. El Bassossy, Chemical Constituents and Biological Activity of Forsskaolea viridis Aerial parts. Life Sci J 2024;21(1):18-25]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com.02.doi:10.7537/marslsj210124.02.

Key words: Forsskaolea viridis, phenolics, flavonoids, antimicrobial, antioxidant, antitumor

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A Voice Initiated Smart Auto-Tracking Mobile Vehicle

 Chian-Yi Chao

Department of Electronic Engineering, Kao Yuan University, Kaohsiung, Taiwan

t10049@cc.kyu.edu.tw

Abstract: This paper proposes a voice initiated smart auto-tracking mobile vehicle which can go start, stop, forward, backward, left turn and right turn automatically based on the received signal from a voice and the detected optical sensors. The proposed auto-tracking mobile vehicle is mainly constructed by AT89S51 based main control board and 8255 input/output peripheral board. Both commercial boards were built by Taiwan Embedded Microcontroller Development Institution (TEMI). In this paper, the AT89S51 microcontroller is used for software programming control and 8255 parallel input/output extension chip for hardware peripheral control. According to the experimental results, the developed smart auto-tracking mobile vehicle can be initiated either by a voice or a push button as well as automatically terminated at the end of track with the ‘T’ mark, where the track is built by sticking the black tape on the ground. Conclusively, the designed auto-tracking mobile vehicle can provide students with brainstorm training opportunity in planning, designing and implementing the microcontroller based project.

[Chian-Yi Chao, A Voice Initiated Smart Auto-Tracking Mobile Vehicle. Life Sci J 2024;21(1):26-32]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 03. doi:10.7537/marslsj210124.03.

Keywords: Auto-tracking, microcontroller, and AT89S51

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Gamma ray effects as oxidant stress on several physiological cases of an adult chickens

Qusay Kh. Al-Dulamey ¹, Rana Hesham Mahmood ², Jihan Adil Fadhil³

¹College of Science /Biophysics Department/University of Mosul/IRAQ

²College of Science / new and renew energies Department/University of Mosul/IRAQ

³College of Education for Human Sciences / Educational and Psychological Department/University of Mosul/IRAQ

Abstract: The aims of this work to find the biophysical effects of gamma ray as oxidation stress on reproductive system of adult chickens. From this work we used cocks chicken at 36-58 weeks of age and found the value of semen volume in (ml/brid/ejac), semen concentration in (Million cells /ml.) and total sperm (million cells/ejaculation) the value of semen volume, semen concentration and total sperm significant increase with increased the age of cocks chicken and considered as control group .Also we found the value of them at irradiation with low dose of gamma ray (33,42, and 75 mGy/h) as chronic dose at 8 h/day for 40 days which significant decrease with increase low dose gradually. The decrease ratio of semen volume with irradiation doses about 5-14% and in semen concentration about 5-12 % for three chronic low doses compared with control group.

[Qusay Kh. Al-Dulamey, Rana Hesham Mahmood, Jihan Adil Fadhil. Gamma ray effects as oxidant stress on several physiological cases of a adult chickens. Life Sci J 2024;21(1):33-37]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 04. doi:10.7537/marslsj210124.04.

Keywords: gamma ray , cocks, irradiation , semen volume , sperm of chicken

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Protective Effect of Hesperidin against Methotrexate-Induced Nephrotoxicity in Rats

Sara A. Aldossary

Pharmaceutical Sciences Department, College of Clinical Pharmacy, King Faisal University, Alahssa, Saudi Arabia

saldossary@kfu.edu.sa

Abstract: The present study investigated the probable protective effect of hesperidin against kidney injury induced by methotrexate in rats. The rats received a single injection of methotrexate (20 mg/kg, i.p.). Hesperidin treatment (100 mg/kg/day, p.o.) was started 1 day before administration of methotrexate, and continued for 7 days. Methotrexate significantly increased serum creatinine, and renal malondialdehyde, nitric oxide, tumor necrosis factor-α, nuclear factor-κB p65, and caspase-3, and significantly decreased renal total antioxidant capacity in rats. Hesperidin significantly ameliorated the changes of biochemical parameters induced by methotrexate. Hesperidin also significantly reduced methotrexate-induced histopathological kidney tissue injury. In conclusion, hesperidin significantly protected against methotrexate-induced kidney injury in rats by inhibiting oxidative/nitrosative stress, inflammation, and apoptosis.

[Aldossary SA. Protective Effect of Hesperidin against Methotrexate-Induced Nephrotoxicity in Rats. Life Sci J 2024;21(1):38-42]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 05. doi:10.7537/marslsj210124.05.

Keywords: Hesperidin; methotrexate; nephrotoxicity; rats

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Identification and Authentication of Microbes Causing urinary tract infection and Detection of Antibacterial Activity for Methanolic Extract of Senna alexanderina against these Pathogenic Bacteria in Khartoum State, Sudan

Abubker, O. Babiker^1*, Areeg, A. Abdelwakeel², Ibrahim F. Ahmed³, Ahmed, A. Elshikh^4*

Abstract: The aim of this study is to isolate and identify the microbes causing urinary tract infection and antibacterial of those microbes by used methanolic extract of plant and antibiotics. One hundred samples were collected for both genders in Khartoum State. From sixty-three out of one hundred samples obtained on different types of microbes are Staphylococcus aureus (33.3%), Enterococcus fecales (9.5%), Escherichea coli (19%), Klebsiella pneumonae (7.9%), Protus mirabilis, Pseudomonas aeuroginosa (9.5%), Citrobacter ssp (4.7%), Candida .albicans (7.9%). The antibacterial results against isolated microorganisms using methanolic extract of Senna alexanderina showed resistance to these microbes except S. aureus was sensitive; also, most microbes were sensitive to antibiotics.

[Abubker, O. Babiker, Areeg, A. Abdelwakeel, Ibrahim F. Ahmed, Ahmed, A. Elshikh. Identification and Authentication of Microbes Causing urinary tract infection and Detection of Antibacterial Activity for Methanolic Extract of Senna alexanderina against these Pathogenic Bacteria in Khartoum State, Sudan. Life Sci J 2024;21(1):43-48]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 06. doi:10.7537/marslsj210124.06.

Keywords: urinary tract infection, methanolic extract, Senna alexanderina, Pathogenic Bacteria, Microbes

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Chemistry of blood stain removal after setting

AZEEZ MUTIU O, RLLD, CLLM, CText ATI

FEDERAL MEDICAL CENTRE, BIRNIN KEBBI, KEBBI STATE, NIGERIA.

Author’s email: azeemone@yahoo.co.uk ,Phone: +2348035283072

ABSTRACT: Blood stains adherence to textile materials or fabrics or hospital linen had been among major challenging stains aside dye transfer from one textile to another. There are many stain removals developed to deal with these problems by different chemical companies globally. All these products have their adverse effects on the properties of the textile fibres that composed the material. For instance, chlorine bleach or oxalic acid can cause tendering of cellulosic fibre like cotton. To remove blood stain, it requires understanding basic chemistry of blood and its constituents. Therefore, other potential stain removals used in this study include: water, detergent, oxalic acid, sodium hydroxide, and alkaline sodium hydrosulphite. Method of data analysis involved evaluation of blood stained fabric sample after treatment through physical comparison of the degree of whiteness obtained with the original white sample (control sample). It was found that sodium hydroxide gave significant removal of the stain, followed by alkaline sodium hydrosulphite while the rest did not show any significant removal.

[AZEEZ MUTIU O, RLLD, CLLM, CText ATI. “chemistry of blood stain removal after setting”. Life Sci J 2024;21(1):49-54]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 07. doi:10.7537/marslsj210124.07.

Keywords: blood stain, sodium hydroxide, oxalic acid, detergent, sodium hydrosulphite

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