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Treatment of Acne vulgaris with Adaplane-Benzoyl Peroxide Topical Gel Formulation and Control and the Effects of Treatment Psychology

Monireh Saeidpour

Faculty of Pharmacy, Near East University, 99138 Nicosia, TRNC, Mersin 10,Turkey.

monirehsaeidpour@gmail.com

Abstract: Binary vulgaris is a very common disease among adolescents. Due to the effects it has on people's faces, it can impose many social and psychological costs on patients, so the treatment of this disease in addition to a health need is a social necessity. It is psychological. Therefore, in this study, Adapalene 0.1% and benzoyl peroxide 2.5% in a gel formulation were formulated for the first time in IRAN to guarantee better results and increase patients' acceptance of these two drugs at the same time. In the first stage, several formulations will be prepared using various jellies, which contain both benzoyl peroxide and adapalene, as well as other compounds such as hemoquantum, protective, etc. In the second stage, the various formulations prepared will be tested for physicochemical control. Control tests include determining the amount of active ingredient, checking for release simultaneously with the manufacture of the products, accelerated stability tests will be performed on the formulation to select the desired formulation based on the results of the control tests. In this work, we made eighty formulations, of which three formulations had the best physical and functional stability. Among them, la formulation was determined as the superior formulation and various physicochemical and microbial tests were performed on this formulation, all of which will confirm the superior product production method.

[Monireh Saeidpour. Treatment of Acne vulgaris with Adaplane-Benzoyl Peroxide Topical Gel Formulation and Control and the Effects of Treatment Psychology. Life Sci J 2022;19(3):1-10]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 1. doi:10.7537/marslsj190322.01.

Keywords: Acne treatment, adapalene topical gel control, benzoyl peroxide, vulgaris

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Salivary Epidermal Growth Factor Level in Recurrent Aphthous Ulcer Patients and Smokers: A Comparative Study

Sahar Mahmoud ElRefai¹, Maha Galal Omar², Ghadeer Ghalab Almutairi³, Shahad Saad Alkait³, Fatimah Salim Almufarji³, Ishrat Rahmand⁴

¹ Assistant Professor of Oral Pathology, Department of Basic Dental Science, Princess Nourah Bint Abdul Rahman University, College of Dentistry

² Professor of Oral Medicine and Diagnosis, Department of Basic Dental Science, Princess Nourah Bint Abdul Rahman University, College of Dentistry

³ General dentist, Princess Nourah Bint Abdul Rahman University, College of Dentistry

⁴ Assistant Professor of Pharmacology, Department of Basic Dental Science, Princess Nourah Bint Abdul Rahman University, College of Dentistry

g.g.alhumaidani@gmail.com

Abstract: Salivary epidermal growth factor (EGF) plays a major role in protection against injuries and helps in maintaining the integrity of oral mucosa by regulating epithelial cell proliferation, growth, and migration. A comparison of EGF level of saliva between smokers, patients who have aphthous ulcer and healthy control group revealed that the mean salivary EGF value in the smoker-group was higher in comparison to the control group. Moreover, the mean salivary EGF value in the recurrent aphthous ulcer) RAU (group was lower than the control group. However, there was no statistically significant difference between the three groups (p=0.222). Nevertheless, salivary epidermal growth factor has an effective impact on the restoration and prevention of recurrent aphthous ulcer. Increased EGF in smokers would be an intermediate circlet for the effect of smoking on the development of RAU.

[Sahar Mahmoud ElRefai, Maha Galal Omar, Ghadeer Ghalab Almutairi, Shahad Saad Alkait, Fatimah Salim Almufarji, Ishrat Rahmand. Salivary Epidermal Growth Factor Level in Recurrent Aphthous Ulcer Patients and Smokers: A Comparative Study. Life Sci J 2022;19(3):11-15]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 2. doi:10.7537/marslsj190322.02.

Keywords: Salivary epidermal growth factor; EGF; smokers; aphthous ulcer; RAU.

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Analysis of COVID-19 vaccination status and adverse events following immunization against SARS-CoV-2 (COVID-19) in a district of Anyang City in 2021

Chunyan Xu, Ke Li, Jingyi Yuan, Rong Zhou, Chaomei Jin, Linlin Jiao, Fang Zhou*

College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China

Zhoufang@zzu.edu.cn

Abstract: To analyze COVID-19 vaccination status and adverse events following immunization (AEFI) against SARS-CoV-2 (COVID-19) in a district of Anyang City in 2021. The vaccination data and data of the AEFI against the COVID-19 vaccine were obtained through the China Immunization Planning Information Management System from January 1 to December 31, 2021. For AEFI surveillance data, descriptive epidemiological methods were used to describe its distribution and statistical tests were performed on the differences between different types and doses by SPSS21.0 (Armonk, NY, USA, 2012) (P < 0.05). The incidence rate (IT) of AEFI was calculated for 100,000 doses applied. In 2021, a total of 1,167,784 doses of the COVID-19 vaccine were vaccinated in a district of Anyang City. The cumulative number of vaccinations of different types and doses varies greatly; the cumulative number of vaccinations varies greatly in different months and regions; the ratio of cumulative vaccination doses for men and women is 0.99:1; 43.22% vaccinated people were aged 18 to 49. In 2021, a total of 124 cases of the AEFI against the COVID-19 were reported in a district of Anyang City. The reported IT was 10.62/100,000 doses; the number of reported cases in different months and regions varies greatly; It is within 1 day between inoculation and the occurrence, between the occurrence and discovery among AEFI cases; The ratio of male and female AEFI cases was 0.79:1; 52.42% AEFI cases were mainly between 18 and 49 years old; General reactions were mainly high fever (body temperature ≥ 38.6°C); abnormal reactions were all allergic reactions. There were statistically significant differences in the reported AEFI between different types and doses (P<0.05). The COVID-19 vaccination (Adenovirus Type 5 Vector) had the highest incidence; the third dose had the highest incidence; 99.19% of cases were cured. In 2021, the AEFI monitoring sensitivity is quite different in different regions; the AEFI against COVID-19 has a low incidence rate and good prognosis and the vaccination is safe for the population.

[Chunyan Xu, Ke Li, Jingyi Yuan, Rong Zhou, Chaomei Jin, Linlin Jiao, Fang Zhou. Analysis of COVID-19 vaccination status and adverse events following immunization against SARS-CoV-2 (COVID-19) in a district of Anyang City in 2021. Life Sci J 2022;19(3):16-22]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 3.doi:10.7537/marslsj190322.03.

Keywords: COVID-19 vaccine; adverse events following immunization; Mass vaccination; Safety

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[Life Sci J 2022;19(3):23-27]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 4.

Withdrawn

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Role of Microbial and Biopesticides in Plant Protection

Muhammad Haseeb^1*, Rukhsana Nazir^1*, Huma Sajjad², Maida Shahid³, Muhammad Ubair Arif⁴

¹Department of Plant Pathology, University of Agriculture, Faisalabad, Pakistan

²Department of Microbiology, Government College University, Faisalabad, Pakistan

³Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan

⁴Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad, Pakistan

*Correspondence email: haseebwahla3360@gmail.com; rukhsananazir99@gmail.com

Abstract: Extensive and inappropriate pesticide use has caused pest resistance to major groups of pesticides, resurgence of secondary pests, high pesticide residue in the produce and decimation of natural enemies. Their excessive use has caused adverse effects on human beings and environment. An ecofriendly alternative to chemical pesticides is biopesticides. Biopesticides are natural, biologically occurring compounds that are used to control various agricultural pests infesting plants in forests, gardens, farmlands, etc. There are different types of biopesticides that have been developed from various sources. Botanical pesticides are assumed to be effective against various crop pests, and they are easily biodegradable and available in high quantities and at a reasonable cost. Plants and microbes are the important components of ecosystem, and their interactions help in regulating the biogeochemical cycle in the environment. Plant-associated microorganisms include bacteria, fungi, and viruses use host plants for their growth, colonization, and proliferation; however, they offer a variety of benefits to the hosts. These microbes are not harmful to the plants; however, they secrete some beneficial substances which may help in plant growth promotion, resistance to pathogenic microbes, removal of harmful contaminants, and production of secondary metabolites.

[Muhammad Haseeb, Rukhsana Nazir, Huma Sajjad, Muhammad Ubair Arif. Role of Microbial and Biopesticides in Plant Protection. Life Sci J 2022;19(3):28-33]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 5.doi:10.7537/marslsj190322.05.

Key words: Biopesticides, microbial pesticides, Plant protection

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A Review of Vision-Based Perceptive Interfaces: A Mouse Alternative

Tariq UU, Asif MDA, Yousaf MH, Hussain F, Rizwan M, Asim MM, Baloch NK

Abstract:-  GUI interfaces based on WIMP (Window, Icon, Menu, Pointer) paradigm has been a popular choice of interface for many systems and has made Human-Computer interaction simpler and easier. In the past few decades great research efforts have been made to make HCI more human like. The Perceptual User Interfaces aims to focus this new form of HCI. In this study we describe different Vision Based Perceptive Interfaces that make use of different computer vision techniques for tracking and gesture recognition that may serve as an alternative for traditional mouse.  The major focus of the work presented here is on the critical evaluation of different vision-Based interfaces that will give the perceptual ability of vision to computers and will make human-Computer interaction more human to human like interaction. The comparative study and critical evaluation using HCI approaches highlights the strength and weakness of the existing vision-Based interfaces. The emphasis of our research is focused on summarizing the literature by highlighting its limitations and strengths.

[Tariq UU, Asif MDA, Yousaf MH, Hussain F, Rizwan M, Asim MM, Baloch NK. A Review of Vision-Based Perceptive Interfaces: A Mouse Alternative. Life Sci J 2022;19(3):34-43]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 6. doi:10.7537/marslsj190322.06. 

Keywords:- Computer Vision, Perceptual User Interfaces, Vision-Based Interfaces, Gesture Recognition, Feature Tracking.

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Linking of MLH1 Variants with Their Clinical Outcomes

Chunhong Zhang¹, Weisheng Ye²

¹Department of Spinal Surgery III, ²Department of Orthopedic Trauma, Tianjin Hospital, Tianjin, China

13132065700@163.com; yeweisheng@yahoo.com.cn

Abstract: In this study, we use the cross-impact analysis to establish a quantitative relationship between mutated primary structure of MLH1 protein and its clinical outcomes using the amino-acid distribution probability as a measure to determine the magnitude of changes in primary structure of MLH1 due to mutations. Then, we use the Bays’ equation to calculate the probability of occurrence of long-QT syndrome under a new variant. Thereafter, we numerically compare altered protein functions with the help of amino-acid distribution probability. Finally, we use the amino-acid distribution probability to find the mutation trend in 155 variants. The results are not only meaningful for clinicians to have a concept on the possibility of occurring of long-QT syndrome when finding a new variant before any sophisticated and expensive tests, but also pave the ways for simulation of relationship between mutated primary structure of proteins and clinical outcome from molecular level.

[Zhang C, Ye W. Linking of MLH1 Variants with Their Clinical Outcomes. Life Sci J 2022;19(3):44-52]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 7.doi:10.7537/marslsj190322.07. 

Keywords: Bayes’ law; cross-impact analysis; distribution probability; MLH1; variant

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Free radical scavenging and ferrous ion chelating activities of citrus fruits derived from induced mutations with gamma irradiation

Min Young Kim

Laboratory of Pharmacology and Toxicology, Faculty of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 690-756, Republic of Korea

jeffmkim@jejunu.ac.kr

Abstract: The antioxidant properties of citrus mutant fruits peel and pulp extracts derived from gamma irradiation were determined for free radical scavenging (DPPH, H₂O₂, NO) and ferrous ion chelation inhibition assays.  Citrus mutant fruit peels exhibited significantly higher activities on H₂O₂ scavenging and metal chelating activities compared with those of citrus wild-type.

[Min Young Kim. Free radical scavenging and ferrous ion chelating activities of citrus fruits derived from induced mutations with gamma irradiation. Life Sci J 2022;19(3):53-56]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 8. doi:10.7537/marslsj190322.08.

Keywords: gamma irradiation; citrus mutants; free radical scavenging activity; ferrous ion chelating activity

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Thermal radiation effects on unsteady free convection flow in a micropolar fluid near a vertical plate with Newtonian heating in the presence of mass diffusion.

1. A. Bakr^1,3, Z. A. S. Raizah¹ and A.M. Elaiw^2,3

¹Department of Mathematics, Faculty of  Science for Girls. Abha, King Khaled University, Saudi Arabia.

²Department of Mathematics, Faculty of Science,  King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi  Arabia

 ³Department of Mathematics, Faculty of Science, Al-Azhar University, Assiut, Egypt. aa_bakr2008@yahoo.com

Abstract: The effects of chemical reaction and thermal radiation on unsteady free convection flow of a micropolar fluid  past a semi-infinite vertical  plate embedded in a porous medium in the presence of heat absorption  with Newtonian heating have been investigated. Both physically important boundary conditions of uniform wall concentration (UWC) and uniform mass flux (UMF) are considered. Rosseland diffusion approximation is used to describe the radiative heat flux in the energy equation. Numerical results of velocity profiles of micropolar fluids are compared with the corresponding flow problems for a Newtonian fluid in UWC and UMF cases. Graphical results for velocity, temperature and concentration profiles of both phases based on the analytical solutions are presented and discussed. Finally the effects of the pertinent parameters on the skin friction, couple stress and the rate of heat transfer coefficient at the plate are discussed.

[A. Bakr, Z. A. S. Raizah and A.M. Elaiw. Thermal radiation effects on unsteady free convection flow in a micropolar fluid near a vertical plate with Newtonian heating in the presence of mass diffusion. Life Sci J 2022;19(3):57-69]. ISSN 1097-8135 (print); ISSN 2372-613X (online). http://www.lifesciencesite.com. 9. doi:10.7537/marslsj190322.09. 

Keywords: Micropolar fluid; thermal radiation; chemical reaction; heat and mass transfer; Newtonian heating.

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