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Evaluation of Strontium Ranelatein Gingival Recession Treatment: Histological Study in dogs.

Enas Ahmed Elgendy¹, Amel M. Ezzat Abd-Elhamid², Doaa A. Taiema³, Alaa M. Metwalli Moustafa⁴.

¹Associated Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry Kafr El-Sheikh University, Egypt

²Associated Professor of Oral Biology, Faculty of Dentistry Tanta University, Egypt

³Lecturer of Oral Biology, Faculty of Dentistry, Tanta University, Egypt

⁴Associated Professor of Surgery, Anesthesia and Radiology, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Egypt

enaselgendy2005@yahoo.co.uk, amezzat26@hotmail.com, dodofirstmolar@gmail.com, ametwally@rvc.ac.uk

Abstract: Background: Gingival recession is the term describing the root surface's oral exposure as a result of the dislocation of the apical gingival border to the cement-enamel connection. Recently, strontium ranelate is an active drug used for the osteoporosis treatment, through stimulation of new bone tissue formation and suppress resorption of bone. The aim of the present investigation is to study the impacts of strontium ranelate membrane on gingival recession induce in dogs. Methods: In this study 8 adult male mongrel animal, buccal gingival recession (GR) deficiencies (upper right and left canine deficiencies in each dog) were created surgically under general anaethesia. Each GR defect was subjected to one of two therapy methods: methyl cellulose membrane with coronally advanced flap (group I control) or strontiumranelate membrane with coronally advanced flap (group II experiment). The experimental animals were killed at 8weeks after given high dose of anesthetic agent and the specimens were processed for histometric and histological examination. Results: Histological results revealed marked regeneration in strontium ranelate membrane group compared to control group. Hestometric research showed a significant rise in the formation of new bone and cement in group II instead of group I. There was also a significant decrease in amount of epithelium down growth in group II than control group. Conclusion: Strontiumranelate membrane is safe, inexpensive and induce regeneration in periodontal defect induced in dogs.

[Enas Ahmed Elgendy, Amel M. Ezzat Abd-Elhamid, Doaa A. Taiema, Alaa M. Metwalli Moustafa. Evaluation of Strontium Ranelatein Gingival Recession Treatment: Histological Study in dogs. Life Sci J 2019;16(12):1-10]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 1. doi:10.7537/marslsj161219.01.

Keywords: Evaluation; Strontium; Ranelatein; Gingival; Recession; Treatment; Histological Study; dog

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Study Planting Methods to Improve Water Use Efficiency and Productivity of Sugar Beet in a Newly Reclaimed Area

Moursy, M.A.M.¹ and M.S. El-Kady²

¹Water Management. Res. Inst., NWRC, Egypt.

²Sugar Crops Res. Inst., Agri. Res. Center, Giza, Egypt.

Moh_chalaby2006@yahoo.com, mohamed_anter@nwrc.gov.eg

Abstract: The present research was implemented at Wadi El-Natrun Research Station in the western desert of Egypt to investigate the effect of different planting methods of sugar beet (traditional and transplanting) on water requirement, water saving, growth analysis, net return, quality and yield of mono and multi-germ sugar beet varieties grown under sandy soil conditions. Results revealed that planting sugar beet using transplanting method resulted in the highest water use efficiency, root and sugar yield, and net return, compared with that sown traditionally using dry seeds, in both growing seasons. Multigerm varieties recorded the highest significant leaf area index, crop growth rate, sucrose and extractable sugar percentages in both seasons. Irrigation water requirements decreased by (27.6, 26.5), (22.2, 21.6) and (10.4, 9.9) % by increasing transplanting period to 30 days from planting compared to 0 (direct sowing), 10 and 20 days transplanting period in the first and second season, respectively. The highest root water use efficiency values were obtained when sugar beet transplanting 30 days and with mono-germ variety (11.84 and 13.26) kg/m³, respectively). However, the lowest values of them (7.29 and 8.47 kg/m³, respectively) were obtained when using the traditional method with multi-germ variety in the first and second season, respectively. Transplanting 30 days saved water by about 26.8 and 26% compared with traditional method in the first and second season.

[Moursy, M.A.M. and M.S. El-Kad. Study Planting Methods to Improve Water Use Efficiency and Productivity of Sugar Beet in a Newly Reclaimed Area. Life Sci J 2019;16(12):11-19]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 2. doi:10.7537/marslsj161219.02.

Keywords: Economic analysis, sugar beet, transplanting, water saving, yield

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Assessment of the muscular power index using infrared technology

Mohammed Nader Shalaby¹, Mona Mostafa Abdou Sakoury² and Marwa Ahmed Kholif^3, Mona Fathi Rizk⁴

¹Associate Professor of Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Egypt

²Assistant Professor, Deanship of preparatory year and supporting, Imam Abdulrahman Bin Faisal University, KSA

³ Assistant Professor, Deanship of preparatory year and supporting, Imam Abdulrahman Bin Faisal University, KSA

⁴ Assistant Professor, Faculty of Applied Studies and Community Service, Imam Abdulrahman Bin Faisal University, KSA

dr.m.nader@a-edu.suez.edu.eg; dr.m.nader@hotmail.com;

Abstract: This research aims at assessing the muscular power index using the infrared technology. The researcher used the descriptive curriculum in the survey method as it is appropriate for the research procedures. The research sample is consisting of 8 youths born in 2004 aged less than 14 years old. The researcher used the OptoGait equipment to measure the variables of the muscular power (the capability to jump) by using on the infrared technology (jumping three meters using three barriers). The variables are as follows: (1) Contact time. (2) Flight time. (3) Elevation of center of gravity. (4) Power. Used tests: (1) Squat Jump Left leg5 times. (2) Squat Jump Right leg5 time. (3) Double legs squat jump. The researcher found that the average level of players in the height of the center of gravity from the ground "the jump height" is 25.8 cm which is an average less than required as the high level of the same age is 39.87 cm (15.7 inches). The researcher recommended using modern technological equipment in measurements such as the OptoGait to guarantee the accuracy, objectivity and quickly results extract. The researcher also refers to the importance of developing and improving the muscular power programs by exercising the bolometric training and the lengthening and default cycle to apply the principle of specialization in training.

[Mohammed Nader Shalaby, Mona Mostafa Abdou Sakoury and Marwa Ahmed Kholif, Mona Fathi Rizk. Assessment of the muscular power index using infrared technology. Life Sci J 2019;16(12):20-31]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 3. doi:10.7537/marslsj161219.03.

Keywords: Muscular power; infrared technology; OptoGait

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The acoustic correlates of Arabic affricates

Eman Ezzat¹, Megahed M. Hassan²

¹Lecturer of Phoniatrics, Department of Oto-Rhino Laryngology, Faculty of Medicine, Menoufia University, Menoufia Egypt

²Assistant Professor of Phoniatrics, Department of Oto-Rhino Laryngology, Faculty of Medicine, Sohag University, Sohag Egypt

E-mail: emezzat50@yahoo.com

Abstract: Background/Aim: The lack of studies addressing Arabic language affricate sounds spurred us to conduct this study that aimed to make a comprehensive inventory of affricate consonants either in Classical Arabic language or colloquial language among Egyptians in order to establish their extent and their analytical acoustic cues (acoustic correlates) that theoretically should be affected in different speech and language disorders. Material and method: The data was collected from 20 native Egyptian speakers from different areas of Egypt (Sohag and Menoufia Governorates). The average age of the participants was 37.8±7.13 years. Acoustic analysis of a list of 51 canonical words that divided into three groups: G1; 6 English words including major affricates, G2; 18 words of alleged affricates, G3 27 words of corresponding stop+fricative sequence. Silence duration, the duration of the internal vowel, frication duration, overall CC or C-C duration, the rise time of the frication part, steady+decay part duration, and amplitude rise slope were measures, tabulated and analyzed. Results: No statistically significant difference was detected between G1 and G2 as regard the overall duration while there were highly statistically significant differences (P˂0.001) when comparing G3 with G1 and G2. Silence duration was significantly longer in final position than middle position in G1 and G2 while there were no significant differences in frication durations in initial, middle, or final positions in all groups. Both rise time and steady+decay part durations showed highly significant relation when comparing G3 with both G1 and G2. Conclusion: Arabic is a rich language with meanings and sounds that not found in many other languages. Arabic affricates are not only /t͡ʃ/ and /d͡ʒ/ but they include t͡s, g͡z, k͡s, q͡ş, k͡f, and b͡ʃ that varying in their lengths between short and long ones. Any combination of consonant stop and phonologically distinctive geminate with no vowel between them or an isolated consonant stop with no vowel and a non-geminate fricative in the same syllable can be received as affricate.

[Eman Ezzat, Megahed M. Hassan. The acoustic correlates of Arabic affricates. Life Sci J 2019;16(12):32-40]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 4. doi:10.7537/marslsj161219.04.

Keywords: Arabic affricates, silence duration, frication duration, Rise time, acoustic correlates

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Relationship of thyrotropin level and bone mineral density in adult females

Tarek A. Hasan¹, Zeinab Abd Elbasset¹, Nagwa Abd El-Ghaffar², Eman M. Aly¹ and Shimaa M. Abdel Kareem¹

¹Endocrinology Department, Department Faculty of Medicine for Girls Azhar University, Egypt.

²Clinical and Chemical Pathology Department, National of Research Centre, Egypt.

shimaakhallaf2014@gmail.com

Abstract: Objective: objective we aimed to examine the association between bone mineral density (BMD) and serum TSH level in premenopausal Egyptian females receiving thyroxin treatment. Methods in this study a total of 90 women receiving thyroxin treatment. aged 35-45 years or older who underwent bone mineral density (BMD) measurement, thyroid function test, osteocalcin and deoxypyridinolin assessment; They were recruited from al Zahra university hospital outpatient endocrinology clinic. The 90 females were divided according to thyroid stimulating hormone (TSH) level into: Group 1: 30 females with low TSH level (suppressive therapy following surgical removal of thyroid cancer), Group 2: 29 females with normal TSH level (hypothyroid females on thyroxin replacement therapy (Controlled on treatment), Group 3: 31 females with High TSH level (hypothyroid females on suboptimum dose of thyroxin replacement therapy. Results there is no statistical significant difference between (weight, height, BMI and waist circumference) among the three groups, this could be explained by the selection criteria of the patients as our study population were not obese or having high body mass index being weight and BMI matched. There were high significant difference between Group 1, 2 and 3 as regard Z score femoral, humerous and spine, In the present study Z score was lower in Group 1 (low TSH) (differentiated thyroid cancer) in comparison to Group 2 & 3, although the overall reduction did not reach the osteoporotic level. Group 2 (women with normal TSH) had the most favorable BMD in comparison to Group 1 & 3. Also Group 3 (high TSH due to suboptimum dose of thyroxin) had better BMD in comparison to Group 1 (women having low TSH due to suppressive therapy). considering the whole studied population, TSH was not correlated with the Z score of femur, humerous or spine, but it was positively correlated with z score of humerous in Group 2 (Normal TSH). FT3 was negatively correlated with spine z score in Group 1 (low TSH). both humerous and spine have significant correlation with either TSH, Free T3 or free T4, although femur had no correlation with TSH, free T4 or Free T3. In the present study, FT4 was correlated negatively with spine Z score in all studied population in all study population. Also, it was correlated negatively with humerous z score in Group 1 (low TSH) and negatively with spine z score in Group 2. there were increase in osteocalcin in low TSH (Group 1) and high TSH (Group 3) than normal TSH (Group 2). it was higher in the low TSH (Group 1) with statistical significant difference. (p<0.01). (p =0.007). Group 1 has higher osteocalcin level than Group 2 and 3. Osteocalcin has positive relationship with serum TSH levels and indicators of the used bone formation marker (osteocalcin). We also found a negative correlation between FT3 and osteocalcin, In the present study, As regard deoxypyridinolin (DPD) we Found that there is high statistical significant difference between Group 1, 2 and 3 (p<0.001) (table) In this study DPD values were highest in Group 1 (low TSH), while being lowest in Group 3 (high TSH) Group , Receiver operating characteristic analysis (ROC) was mad between patients with osteoporosis and patients without osteoporosis to TSH, osteocalcin and DPD TSH cut off values were (=OR<0.05), (>9.7) and (=OR>3.5) previous values are accepted for screening the risk of osteoporosis in patient receiving thyroxin treatment.

[Tarek A. Hasan, Zeinab Abd Elbasset, Nagwa Abd El-Ghaffar, Eman M. Aly and Shimaa M. Abdel Kareem. Relationship of thyrotropin level and bone mineral density in adult females. Life Sci J 2019;16(12):41-45]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 5. doi:10.7537/marslsj161219.05.

Keywords: Relationship; thyrotropin; level; bone; mineral; density; adult; female

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Antifungal activity of Essential Oils of Moringa Oleifera and Punica Granatum Seeds against Candidal Vaginitis in Mice Model

Khulud Alshehri

Biology Department, AL-Baha University, Baljurashi, Saudi Arabia

dr.k2015@hotmail.com

Abstract: Moringa oleifera (M. oleifera) and Punica granatum L (P. granatum L) are two of important plants found in different parts of Al-Baha region, Saudi Arabia, the seeds essential oils of the two plants have broad spectrum antimicrobial activity against a lot of pathogens. Candida albicans (C.albicans) is a common cause of mucosal infectious disease in women in the form of candida vaginitis. Marked resistance by the microorganisms to conventional antifungal drugs has been documented, so the study designed to evaluate the effect of M. oleifera and P. granatum seeds essential oils on infections caused by C.albicans (candidal vaginitis) using mice model. The essential oils were extracted with n-hexane and soxhlet extractor and tested its activities. Agar diffusion method, minimum inhibitory concentrations (MIC) and Minimal fungicidal concentration (MFC) were performed in vitro and histological diagnosis using H & E and PAS stains. The M. oleifera E.O showed high ability to inhibited candidal growth compared to the P. granatum L E.O with 18.3 ±1.5mm inhibition zone and MIC & MFC were recorded 0.0312 mg/ml and 0.0625 mg/ml respectively. The P. granatum L E.O gave 12.7 ±1.5 mm inhibition zone and MIC & MFC were recorded 0.0625mg/ml and 0.125 mg/ ml respectively. The lost of squamous epithelium cells without hyphae appeared in histological examination of M. oleifera treated group. Clear ability to recover vaginal lumen from C. albicans infection showed in histological sections of P. granatum E.O compared to infected non treated group. The results of the present study indicated that seeds E. Os of M oleifera and P. granatum exhibited strong antifungal activity against candidal vaginitis in mice.

[Alshehri K. Antifungal activity of Essential Oils of Moringa Oleifera and Punica Granatum Seeds against Candidal Vaginitis in Mice Model. Life Sci J 2019;16(12):46-51]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 6. doi:10.7537/marslsj161219.06.

Key wards: Antifungal activity, Essential Oils, Moringa Oleifera, Punica Granatum L, Mice.

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Analysis of The Flouting of Grice's Conversational Maxims By Arab Leaders During Arab Spring

Amer Mohammaed Ayasreh¹, Ali Suleiman Awwad¹, Nada AL-Sabti¹, Nidal Motalq Ayasrah²

^1- Imam Abdulrahman Bin Faisal University, College of Applied Studies and Community Service, P.O. Box 2435, 31441 Dammam, Kingdom of Saudi Arabia.

^2- Imam Abdulrahman Bin Faisal University, Deanship of Preparatory Year and Supporting Studies, P.O. Box 2435, 31441 Dammam, Kingdom of Saudi Arabia.

E-mail: Ayasreh_amer@yahoo.com / amayasreh@iau.edu.sa

Abstract: Theoretically, in communication, speakers must apply the cooperative principle that consists of four maxims of conversation. They are maxim of quality, maxim of relevance, maxim of manner and maxim of quantity. Speakers must follow these maxims in order to have a successful communication without misunderstanding. In fact, speakers sometimes flout the maxims intentionally for a reason. Therefore, the main aims of this study is to investigate the analysis of the flouting of Grice's conversational maxims by Arab leaders during Arab spring and type of maxims flouted by Gaddafi and Assad during interviews with ABC and ARD channels and explain the reasons for flouting the maxims by both leaders in the interviews. Qualitative research design was used to collect data. This study reveals that the four maxims are flouted by the leaders by playing upon words in order to give them meanings in their favor and it shows how the Arab leaders color the choices to produce particular shades of meanings which are not always conceivable to all readers in order to gain the support from the masses.

[Amer Mohammaed Ayasreh, Ali Suleiman Awwad, Nada AL-Sabti, Nidal Motalq Ayasrah. Analysis of The Flouting of Grice's Conversational Maxims By Arab Leaders During Arab Spring. Life Sci J 2019;16(12):52-56]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 7. doi:10.7537/marslsj161219.07.

Keywords: Conversational Maxims; Flouting; Implicature; Arab Leaders; Arab Spring.

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Assessment of Total Mesorectal Excision through the End Pathology Report In Conventional Versus Laparoscopic Rectal Cancer Resection

Mohamed Magdy¹ (MD), Tarek Youssef ¹ (MD, MRCS, FACS), Mohamed Abouzeid¹ (MD), Ibrahim H. Bayan²

¹General Surgery Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

²Armed Forces College of Medicine, Cairo, Egypt.

abouzeid2000@hotmail.com

Abstract: Background: Colorectal cancer represents the fourth commonest malignancy worldwide. Globally, colon and rectal cancer make up 9.4% and 10.1% in men and women of all cancers, respectively. Colorectal tumor is the third most common malignancy after breast and lung cancer. The modern management of rectal cancer involves a multi-disciplinary approach and an individually tailored treatment plan. Operative surgery remains the primary and definitive treatment for locally confined rectal adenocarcinoma and is the only historical and current treatment modality which allows for cure. Resection of the colorectal cancer can be done either by local excision or laparoscopically. Aim of the work: The main objective is to compare the completeness of total mesorectal excision for rectal cancer in both open and laparoscopic surgery through the end pathology report. Methods: In this multicenter, prospective, comparative study, we included the pathologically established rectal cancer patients from 2 hospitals in Cairo, Egypt, Ain Shams University Hospitals and Maadi Military Hospital, Egypt between 2012 and 2014. The total sample size was 40 patients divided into two groups; 20 patients for laparoscopic surgery and 20 patients for the open trans-abdominal surgery. Inclusion criteria: histopathology confirmed rectal cancer, patients fit for operative resection, and with T1, T2 or T3 grades according to the preoperative assessment. The exclusion criteria: Patients with T4 stage tumor, patients present as emergency cases and patients present with recurrence of the tumor and synchronous colonic tumors. Results: The median size of the resected tumor was 4.00±1.98 in the laparoscopy group, while in the trans-abdominal surgery group it was 3.78±1.39. No statistical significant difference was found (p= 0.687). No statistical significant difference was found regarding the Type of the surgical operation. Total operative time was significantly shorter in the trans-abdominal surgery group, while the hospital stay period was significantly shorter in the laparoscopy group. Laparoscopy group also showed significantly time before flatus passage, and the patients in the laparoscopy group started oral intake faster than open surgery group. Conclusion: Long-term clinical outcomes of overall survival and recurrence is the foremost parameters which should be taken in consideration for decision for laparoscopic surgery for rectal cancer. Additional follow-up results from the current trial are presently being developed, beside with records on other secondary end points, like cost effectiveness and quality of life.

[Mohamed Magdy, Tarek Youssef, Mohamed Abouzeid, Ibrahim H. Bayan. Assessment of Total Mesorectal Excision through the End Pathology Report In Conventional Versus Laparoscopic Rectal Cancer Resection. Life Sci J 2019;16(12):57-64]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 8. doi:10.7537/marslsj161219.08.

Keywords: Mesorectal Excision, Conventional Versus Laparoscopic, Rectal Cancer Resection

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Evaluation of Fasting Serum Gastrin Level in Patients with Portal Hypertensive Gastropathy

Yasmine M Massoud¹, Rasha O Refaie², Walid Abdelhady³, Hend M Hussein¹

¹Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

²Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

³Department of Internal Medicine, Faculty of Medicine, Helwan University, Cairo, Egypt.

Email: Yasminemassoud3@gmail.com

Abstract: Aim: To evaluate the fasting serum gastrin level in cirrhotic patients with and without portal hypertensive gastropathy and healthy population and To correlate the fasting serum gastrin level with the severity of hepatic decompensation, portal hypertension and portal hypertensive gastropathy. Methods: This study was performed in the Tropical Medicine department Ain Shams University Hospitals, in Cairo Egypt and included the following: The study included 79 participants. Fifty-four cirrhotic patients, whom were further divided into 25 cirrhotic patients with Portal hypertensive Gastropathy (PHG) diagnosed by esophago-gastro-duodenoscopy (EGD) and 29 cirrhotic patients without PHG excluded by EGD, and a third group of 25 healthy persons. Patients were subjected to Full history taking, general examination, local abdominal examination, liver function tests, HBs Ag and HCV ab. Fasting serum level of Gastrin was done by ELISA technique. Results: In the current study, the mean age of the healthy group was 32.9 years in comparison to 58.2 years and 56.07 years in cirrhotic patients with and without PHG. Esophageal varices and ascites were significantly more common in cirrhotic patients with PHG in comparison to cirrhotic patients without PHG. The comparison between the cirrhotic patients group with and without PHG and the healthy group regarding fasting serum gastrin level revealed that the best cut off value was found to be > 18.1 pg/ml with area under the curve (AUC), 0.900; Sensitivity, 90.74%; Specificity, 80%. As for the comparison between cirrhotic group with PHG and cirrhotic group without PHG regarding fasting serum gastrin level, it revealed that the best cut off value was found to be > 95.6 pg/ml with area under the curve (AUC), 0.786; Sensitivity, 56%; Specificity, 100%. Conclusion: Fasting serum gastrin level may serve as a non-invasive predictor of the presence of portal hypertensive gastropathy in cirrhotic patients.

[Yasmine M Massoud, Rasha O Refaie, Walid Abdelhady, Hend M Hussein. Evaluation of Fasting Serum Gastrin Level in Patients with Portal Hypertensive Gastropathy. Life Sci J 2019;16(12):65-70]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 9. doi:10.7537/marslsj161219.09.

Keywords: Portal Hypertensive Gastropathy (PHG), Gastrin Hormone, cirrhotic patients

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Modified Radical Mastectomy With Extended Latissmus Dorsi Flap Versus Skin Sparing Mastectomy With Sub Pectoral Silicone Implant; A Prospective Evaluation

Rania E Lahmady MD, Ahmed Gamal Eldin MD, M.A. Marzouk MD

General Surgery Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt

dr.raniaelahmady@gmail.com

Abstract: Background: Several types of mastectomy procedures are now available to the breast surgeon. The most commonly performed is total mastectomy, with the removal of the nipple-areola complex (NAC) and the whole breast tissue in addition to the nipple-areola complex skin ellipse. A skin sparing total mastectomy resects all the breast tissue through a circumareolar incision including the resection of the nipple but preserving the skin envelope, thus facilitating immediate reconstruction. Aim of the work: the aim of our work was to compare modified radical mastectomy with extended latissmus dorsi flap with skin sparing mastectomy with sub pectoral silicone implants as regard surgical outcome, patient satisfaction and oncological safety. Patients and methods: This prospective randomized comparative study included 30 patients with invasive breast cancer.15 of them were treated by modified radical mastectomy with extended latissmusdorsi flap (group A) and the other 15 patients were treated by skin sparing mastectomy with sub pectoral silicone implants (group B). The patients were followed up every 3 months for post-operative early and late complications and cosmetic outcome. Result: The mean age for our study was 45.60±5.81. The mean operation time in group A was 3.81±0.76 while in group B was 1.55±0.44 with P value 0.0001 (HS). Postoperative complications occurred in only 10 cases in the form of 4 cases (13.3%) of wound infection and 6 cases (20%) of haematoma. 5 patients from the 6 patients who had haematoma were in group A. The mean of cosmetic outcome score in group A was 1.60±0.74 which fall between poor and good and in group B 4.00 ± 0.93 which fall between good and excellent with P value.001(HS). Conclusion: Skin sparing mastectomy with immediate reconstruction is an excellent choice for cases not suitable for conservative wide local excision provided that there is a good patients’ selection.

[Rania E Lahmady, Ahmed Gamal Eldin, Marzouk. Modified Radical Mastectomy With Extended Latissmus Dorsi Flap Versus Skin Sparing Mastectomy With Sub Pectoral Silicone Implant; A Prospective Evaluation. Life Sci J 2019;16(12):71-79]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 10. doi:10.7537/marslsj161219.10.

Key words: Latissmus dorsi flap, silicone implant, skin sparing mastectomy

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A Novel Technique: Reversed Anastomosis of One Anastomosis Gastric Bypass (OAGB) As a New Technique to Manage Incidentally Found Intestinal Mal-Rotation in Bypass Surgeries

Abd-Allah Hamed, Karim Saabry, Yasser El-Ghamrini

Department of General Surgery, Ain-Shams University Hospitals, Cairo, Egypt

drabdallah333@gmail.com

Abstract: Context: One of the very rare congenital anomalies, is Midgut Malrotation (MM), which is almost always discovered incidentally (during radiology or intraoperative). The frequency of anomaly is usually rare (0.025%) as confirmed by bariatric. Technical adjustments and an alternate surgical approach are needed during correction of MM due to anatomical variations of the laparoscopic gastric bypass and technical understanding during the operation. Objective: The aim of this study was to improvise a new technique in a patient candidate for bariatric surgery with intestinal mal-rotation. Methodology: This study was a cohort retrospective study conducted on five patients with mid-gut malrotation out of 6000 patients who underwent different bariatric surgeries. All patients underwent “one anastomosis gastric bypass” (OAGB), in a standardized modified technique, which was used for all patients with malrotation, where mirroring of the original technique was used. Results: except for one patient (with superadded co-morbidities), all our patients had hospital stay as normal subjects, with no postoperative complications, by using this technique. Conclusion: MM is uncommon congenital abnormality, and it is not a contradict to a surgery for weight loss, but require sophisticated skills of surgeon and a broad knowledge of the anatomic changes to treat any unanticipated perioperative results.

[Abd-Allah Hamed, Karim Saabry, Yasser El-Ghamrini. A Novel Technique: Reversed Anastomosis Of One Anastomosis Gastric Bypass (OAGB) As A New Technique To Manage Incidentally Found Intestinal Mal-Rotation In Bypass Surgeries. Life Sci J 2019;16(12):80-84]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 11. doi:10.7537/marslsj161219.11.

Keywords: Novel Technique; Anastomosis; One Anastomosis Gastric Bypass (OAGB); Technique; Manage; Intestinal Mal-Rotation; Bypass Surgeries

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Impact of physical activity in osteoporosis and alveolar bone protection

F. Marzook¹, Fawzy A. Ali ², El-sonbaty. S³, H. Marzook ⁴ and Elhadry ⁵.

¹Labeled Compound Dept. Hot Lab Centre, Egypt

² Lecturer of Oral Biology, Faculty of Dentistry, Mansura University, Egypt

³Microbiology Departments, National Centre Of Radiation Research and Technology, Egypt

⁴ Associate Professor of Oral Surgery, Faculty of Dentistry, Mansura University, Egypt

⁵Biological Application Department, Nuclear Research Center, Egypt

Abstract: Physical activity protects body bones against osteoporosis in mysterious way and the reason for such improvement was unknown and unclear. We were inspired to search the possible role of allantoin in such improvement being increased in response to physical activity as a metabolic byproduct. Osteoporosis was simulated by gamma irradiation and allantoin was injected in rats as a radiation treatment or prevention. Allantoin improved different bony concerns related to osteoporosis such as alkaline phosphatase, acid phosphatase, uric acid and histochemical profile by using digital image analysis. This study concluded the possible role of allantoin as a key factor in bone improvement in physically active persons; also allantoin can be used as a treatment for osteoporosis and gout with extra advantage of being antioxidant radiation protector.

[F. Marzook, Fawzy A. Ali, El-Sonbaty. S, H. Marzook and Elhadry. Impact of physical activity in osteoporosis and alveolar bone protection. Life Sci J 2019;16(12):85-91]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 12. doi:10.7537/marslsj161219.12.

Keywords: Impact; physical; activity; osteoporosis; alveolar; bone protection

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UV- Spectrophotometric Measurement of Sustained Release of Strontium Renelate Loaded on Platelet Rich Fibrin Membrane: An In-vitro Study

Enas Ahmed Elgendy¹, Malak Yousef Mohamed Shoukheba²

¹Assistant Prof. of Oral Medicine, Periodontology, and Oral Diagnosis Department, Faculty of Dentistry, Kafr El-Sheikh University, Cairo, Egypt.

²Assistant Prof. of Oral Medicine, Periodontology, and Oral Diagnosis Department, Faculty of Dentistry, Tanta University, Cairo, Egypt.

Abstract: Objective: To study the suitability of the platelet rich fibrin membrane (PRF) as suitable scaffold and delivery system to carry and allow sustained-release of strontium ranelate (SR) and whether the SR can decrease degradation process of PRF. Study Design:4 membranes of PRF and 4 membranes of strontium renelate loaded on PRF (SR/PRF) were prepared. 2 membranes of PRF and 2 SR/PRF were examined under electron microscope. 2 membranes of PRF and 2 SR/PRF were investigated to determine the degradation time each one. The concentrations of SR released from the SR/PRF were calculated at 1, 2, 4, 6, 8, 10, 24, 48, 60 and 72 hours by spectrophotometric methods. Results: Electron microscope scan showed that SR was carried on PRF membrane. SR/PRF was found to be degraded slower than PRF membrane. Sustained-release of SR from PRF was found to be continuous from the first hour to the end of 72 hours. Peak concentrations of SR in the degradation solution was reported on the first hour then decreased along 72 hours. Conclusion: SR could be loaded on PRF and it increase the life time of the membrane. SR is released in a sustained manner from PRF membrane.

[Enas Ahmed Elgendy, Malak Yousef Mohamed Shoukheb. UV- Spectrophotometric Measurement of Sustained Release of Strontium Renelate Loaded on Platelet Rich Fibrin Membrane: An In-vitro Study. Life Sci J 2019;16(12):92-98]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 13. doi:10.7537/marslsj161219.13.

Keywords: Platelet rich fibrin, Strontium renelate, Scanning electronmicroscopy, UV spectrophotometry

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Extraheptic Duct injury following blunt Abdominal Trauma: Case report managed with ERCP and Stenting

Sami Alhawassi

Consultant of Surgery, Fellow of Trauma & Acute Care Surgery, Department of Surgery, King Saud University

Abstract: Traumatic injuries of the extrahepatic biliary tract are rare. Associated injuries are usually responsible for immediate indication for surgical treatment, the time when an injury to the extrahepatic biliary ducts may be diagnosed. However, missed injuries are often common. The primary aim of this paper is to describe the clinical features, diagnosis, treatment, and outcome of two patients with left hepatic duct injury after blunt abdominal trauma. A young male, brought by red crescent on 4th June 2017 at night as a victim of MVA, He was the driver, not wearing seat belt, stucked in the car with difficult extraction, no other victims. The patient underwent sphincterctomy and 2 transpapillary stent inserted for common hepatic duct injury. A high level of suspicion is necessary to identify injuries to the hepatic ducts. Early diagnosis that occurs during laparotomy due to associated injuries is important to reduce complications.

[Sami Alhawassi. Extraheptic Duct injury following blunt Abdominal Trauma: Case report managed with ERCP and Stenting. Life Sci J 2019;16(12):99-105]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 14. doi:10.7537/marslsj161219.14.

Keywords: Extraheptic; Duct; injury; blunt; Abdominal; Trauma; Case; report; Stenting

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Evaluation of different oncoplastic procedures used in the treatment of early breast cancer located in the upper outer quadrant

Rania Elahmady MD, Waleed Ibrahem MD, Mohamed Magdy MD

General Surgery Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt

dr.raniaelahmady@gmail.com

Abstract: Background: In order to resolve the conflict between cosmetic satisfaction and oncologic safety a several procedures named "Oncoplastic Surgery" have appeared and gained wide acceptance all over the world. Oncoplastic procedures allow the treatment of large tumors with conservation rather than mastectomy. Aim of work: is to assess the oncoplastic techniques used for treatment of early breast cancer located in the upper outer quadrant which are donut mamoplasty, radial segmentectomy and lateral mammoplasty, as regard oncological safety surgical outcomes and patient satisfaction. Patients and method: This study included 30 female patients with early breast cancer located at upper outer quadrants. They all were treated by wide excision with safety margin followed by immediate reconstruction of defects using donut mammoplasty, radial segmentectomy or lateral mammoplasty; the patients were followed for postoperative complications, cosmetic outcome and local recurrence. Result: the mean age for our study was 48.7±10.27. The mean operative time for Donut mammoplasty was 102.36±9.86 minutes, while they were 100.75±8.47 minutes and 127.57±10.63 minutes for radial segmentectomy and lateral mammoplasty respectively. Donut mammoplasty was a simple technique which had the least amount of intra-operative blood loss, post-operative drain amount and post-operative stay. The mean cosmetic outcome of donut mammoplasty was 4.86 ± 0.40which fall between very good and excellent, for radial segmentectomy was 4.33 ± 0.65 which fall between good and very good and for lateral mammoplasty was 3.14 ± 0.69which fall between fair and very good. Conclusion: The donut mammoplasty technique has the best cosmetic outcome with average simplicity of the surgical procedure; while lateral mammoplasty was the most complex technique with the least cosmetic outcome. Radial segmentectomy was the simplest technique, its cosmetic outcome falls between the other two techniques and it can be done for any breast size.

[Rania Elahmady, Waleed Ibrahem, Mohamed Magdy. Evaluation of different oncoplastic procedures used in the treatment of early breast cancer located in the upper outer quadrant. Life Sci J 2019;16(12):106-114]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 15. doi:10.7537/marslsj161219.15.

Key words: Donut mammoplasty, radial segmentectomy, lateral mammoplasty

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The animal model with warm compression and propranolol to treat SD rats with central serous chorioretinopathy

Wei-Da Chio ¹, Chi-Ting Horng ^2,3*

¹ Departmet of Physical of Rehabilitation, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC.

² Department of Pharmacy, Tajen University, Pingtung, Taiwan, ROC.

³ Departmet of Opthalmology, Fooying University, Pingtung, Taiwan, ROC.

* Corresponding Author：Chi-Ting Horng, M.D. Ph.D., Department of Ophthalmology, Fooying University Hospital, No.5, Zhong-Shan Rd, Donggang, Pingtung, Taiwan, ROC. h56041@gamil.com

Abstract: Aim: This animal study aims to evaluate the prognosis of central serous chorioretinopathy (CSCR) treatment with oral propranolol combined with warm compression every day for 2 months. Methods: The treatment peroid tested 2 months with 16 males SD rats with CSCR, conducted in July 2019. All 16 right eye of cases were randomly divided into 2 groups which underwent a series of examinations including indirect ophthalmoscopy, and OCT scanning every week. Group 1 included 8 SD rats fed with propranolol (10 mg in each day), and warm compressure. The other 8 SD rats in group 2 received placebo treatment. All SD rats were inducted into the CSCR model first, and we recorded the time of total complete remission of sub-retinal fluid. If CSCR disappeared under OCT imaging, the rat was considered as a “successful” case and it stopped taking the drug at once. The other CSCR rats continued to be fed with until the end of the 2nd month. The percentages of “successful” and “un-successful” cases were recorded and all 16 cases received a further 3–month follow-up to evalute the rate of recurrence and the time of success. Moreover, the mean time of complete remission was also calculated at the same time. Results: All 16 male rats were enrolled in our study. Furthermore, the mean time of complete remission in group 1 and group 2 was 0.8, and 1.8 weeks, respectively. The percentages of “successful” cases in group 1 and group 2 after 2-month therapy was 87.5% (7/8) and 62.5% (5/8), respectively (P < 0.05). Besides, the rate of recurrence in group 1 and group 2 was 12.5% (1/8) and 37.5% (3/8) after 3 months, respectively (P < 0.05). Conclusion: We suggest that the SD rats fed with propranolol and combined with warm compression may constitute an alternative choice to treat CSCR. This new method may show the safe, cheap, effective, well tolerated and convenient benefit. Furthermore, it may even shorten the remission time of the course of treatment and decrease the rate of recurrence.

[Wei-Da Chio, Chi-Ting Horng. The animal model with warm compression and propranolol to treat SD rats with central serous chorioretinopathy. Life Sci J 2019;16(12):115-126]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 16. doi:10.7537/marslsj161219.16.

Keywords: Central serous chorioretinopathy (CSCR), Propranolol, ophthalmoscopy

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Incidence and Management of Early Complications of Laparoscopic Sleeve Gastrectomy for morbid obesity; Case series and Literature Review

Waleed Ibrahem, Mohamed Ahmed Rady, Mohamed Abdelsattar Abdelhamid, Mohamed G Qassem.

General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Wibrahem50@gmail.com

Abstract: Background: One of the effective methods used for treatment of obesity is the Laparoscopic Sleeve gastrectomy which is comparatively safe. Diagnosis of leakage is mainly based on clinical suspicion and lab radiological evidence. The Laparoscopic sleeve gastrectomy is superior in comparison to other restrictive procedures due to the decrease of large parts of ghrelin producing stomach mass. Aim of work: To estimate the incidence of early complications following laparoscopic sleeve gastrectomy and how to manage those complications. Patients and Methods: This study is a prospective case series which has been conducted at Ain Shams University Hospitals recruiting 300 patients who underwent laparoscopic sleeve gastrectomy upon between March 2017 and March 2018 with minimal follow up of one month postoperatively. Prospective data were reviewed from patient files. Results: Our study included 300 patients with mean age 37.1 ± 20. The mean body mass index was 41.95 ± 4 while body mass index < 40 kg/ m² was 5% and BMI was 40 -50 kg/ m² was 95%. Medical co-morbidities were in the form of hypertension in 30% of cases, DM in 40% of cases and obstructive sleep apnea in 6% of cases. The operation time was 30-40 min and the average of hospital stay was 1.2 (1-4) days. The postoperative complications were staple line leakage in 0.6% of the cases, staple line he in 0.6% of cases, wound infection in 0.3% of cases, portal vein thrombosis in 0.3% of cases and chest infection in 0.6% of cases. Conclusion: Leakage and hemorrhage after LSG are diagnosed clinically and by radiological investigations. Mesenteric Venous Thrombosis is a subtle complication that warrants high index of suspicion for immediate management. Further studies are needed to detect the best treatment methods for early complications.

[Waleed Ibrahem, Mohamed Ahmed Rady, Mohamed Abdelsattar Abdelhamid, Mohamed G Qassem. Incidence and Management of Early Complications of Laparoscopic Sleeve Gastrectomy for morbid obesity; Case series and Literature Review. Life Sci J 2019;16(12):127-135]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 17. doi:10.7537/marslsj161219.17.

Keywords: Laparoscopic Sleeve Gastrectomy, early complications, leakage, hemorrhage

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Study the Behavior of Beams with Opening in the Shear Zone Strengthendby Carbon, Glass sheet and Steel Fibers

Mostafa Abd El Megied Osman¹, Kholoud Atef Sayed²

¹Associate Professor of Reinforced Concrete, Faculty of Engineering, Helwan University.

²B.Sc.2012, Civil Engineering, Faculty of Engineering -Helwan University.

m_osman62@yahoo.com

Abstract: This study aims to evaluate the improvement of load carrying capacity of reinforced concrete beams with opening in shear zone and strengthened by Steel fiber and Glass, Carbon sheets. Thirteen reinforced concrete (RC) beams with opening in shear zone with a cross section of 150×300 mm and a total length of 1650 mm, were fabricated, strengthened, and loaded up to failure. The results showed that the strengthening with steel fibre and externally bonded glass and carbon strips have obvious enhancement on the general behavior of beams and shear capacty of the opening beams. Also, a reduction in deflection for all strengthened beams was observed.

[Mostafa Abd El Megied Osman, Kholoud Atef Sayed. Study the Behavior of Beams with Opening in the Shear Zone Strengthendby Carbon, Glass sheet and Steel Fibers. Life Sci J 2019;16(12):136-146]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 18. doi:10.7537/marslsj161219.18.

Keywords: Study; Behavior; Beams; Shear Zone; Strengthend; Carbon; Glass; sheet; Fiber

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Improving the ultimate capacity of loaded strip footing using additional contact area under excessive loads

M.N. EL Siragy

Assistant Professor of Geotechnical Engineering, Department of Structural Engineering, Faculty of Engineering – 6 October University, Egypt

Email: siragy2000@yahoo.com

Abstract: The purpose of this paper is to adopt an alternative strategy for strengthening of existed strip footing by increasing the bearing area instead of using the previous methods of soil reinforcement technique. These techniques are rather than prohibitively expensive and restricted by the conditions of the site. The main objective of this strengthening is to improve the bearing capacity under the loaded strip footing to resist additional loads. It also aims to study the effect of the increasing the footing size on the bearing capacity factor (N) and failure mode of the footing. A series of Loading tests on the modified model footing are carried out at different footing widths on sandy soil. The results show that the bearing capacity of widen footings at double side significantly increased. In addition to, the resulting settlement can be decreases. The ultimate load capacity is increased by as much as 140, 218% for additional area ΔB/B = 0.4 and 1 with remarkable reduction in settlement around 45%. The bearing capacity factor affected by the footing size as comprised with different investigators.

[M.N. EL Siragy. Improving the ultimate capacity of loaded strip footing using additional contact area under excessive loads. Life Sci J 2019;16(12):147-153]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 19. doi:10.7537/marslsj161219.19.

Keywords: Improving; ultimate; capacity; loaded strip; footing; excessive loads

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Diet Modification as a Dental Extraction Adjunct in a Diabetic Patient: A Case Report

Nadia A Al-Hazmi

Oral Biology Department, King Abdulaziz University Faculty of Dentistry, Jeddah, Saudi Arabia

nalhazmi@kau.edu.sa

Abstract: Dental extractions may be deferred in uncontrolled diabetic patients until their blood glucose level is under control, thereby delaying treatment and compromising quality patient care. Here we present the case of a sixty-year-old man with uncontrolled diabetes who required dental extraction. After a number of failed attempts at starting the procedure due to high random blood glucose levels, a low glycemic index diet was prescribed based on easy instructions and a local, inexpensive meal. This successfully brought his blood glucose under control, and the procedure was successfully completed without complications. This case highlights how dentists can deliver quality patient care by integrating disciplines related to both prevention and treatment. Dietary guidelines for systemically ill patients undergoing specific dental treatments would be highly desirable to help expedite their recovery.

[Nadia A Al-Hazmi. Diet Modification as a Dental Extraction Adjunct in a Diabetic Patient: A Case Report. Life Sci J 2019;16(12):154-156]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 20. doi:10.7537/marslsj161219.20.

Keywords: Dental Education; Diabetes Mellitus; Diet, Diabetic; Glycemic Index

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Primary Closure versus Choledocho-Duodenostomy after Common Bile Duct Exploration for Choledocholithiasis with Failed ERCP, A Single-Centre Expertise

Mohamed G. Qassem and Mohamed Abdel Sattar Abdelhamid

General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email: mohamed_omran@med.asu.edu.eg

Abstract: Background: Primary Closure (PC) has been widely favoured as a superior method to T-tube drainage for closure of choledochotomy after CBD exploration. Since no studies have compared PC to Choledocho-duodenostomy (CDD), we aim to study the advantages and disadvantages of CDD in comparison with PC. Methods: This is a retrospective cohort study of 40 patients, with failed ERCP for CBD stones. They were followed up for 27±6 months, after performing either CDD or PC as a closure method after CBDE. Both groups were compared according to postoperative morbidity and hospital stay. Findings: Pre-operative cholangitis was recognised in nine cases (45%) who had CDD technique, and in only 3 patients (15%) in the PC arm; p value is 0.038. CBD diameter has been reported as 9.75±1.45 mm and 7.85±1.26 mm in CDD and PC groups respectively, achieving a statistical significance; P value 0.002. The five patients (25%), who were diagnosed to have pre-operative biliary stricture by MRCP, were all offered to undergo CDD rather than PC (P= 0.047). Operating surgeons took 23.5 ± 2.95 minutes to perform CDD, whereas PC technique consumed only 14.85 ± 2.16 minutes, p value was 0.001. There was no significant difference statistically between group one and group two regarding post-operative biliary complications. Conclusion: Although Choledocho-duodenostomy (CDD) significantly elongates the surgical time, it has closely similar results as Primary Closure (PC) in terms of postoperative biliary complications and hospital stay.

[Mohamed G. Qassem and Mohamed Abdel Sattar Abdelhamid. Primary Closure versus Choledocho-Duodenostomy after Common Bile Duct Exploration for Choledocholithiasis with Failed ERCP, A Single-Centre Expertise. Life Sci J 2019;16(12):157-165]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 21. doi:10.7537/marslsj161219.21.

Keywords: Choledocholithiasis, CBD exploration, Primary closure, Choledochoduodenostomy

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