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Morphometric, Histological and Immunohistochemical Study of Tongue Epithelium in Diabetic Rats

Mona A. Abd-Elmotelb

Oral Biology Department, Faculty of Dentistry, Tanta University, Egypt.

mon_assem@hotmail.com

Abstract: Background: Diabetes Mellitus (DM) is one of the most common endocrine metabolic disorders in the world. It is associated with several tissue changes which result in many systemic and oral complications. Aim of study: Investigate the tissue alterations as a result of hyperglycemia on rats tongue epithelium. Material and Methods: Twelve, adult male Sprague–Dawley rats were allocated equally into two groups: Group I (Control) and Group II (DM). Diabetes was induced by a single intraperitoneal injection of aqueous alloxan monohydrate (ALX) After 6 weeks, animals were euthanized, and samples were processed for routine histological Hematoxylin and Eosin (H & E) and immunohistochemical staining for P53 and Ki-67. Student t-test was used to compare P53 and Ki-67 expressions between groups. Results: Morphometric comparison revealed significant reduction in tongue epithelium height in diabetic rats. Histologically, tongue mucosa in diabetic rats showed abnormal epithelial morphology with atypical epithelial ridges. Epithelial cells showed signs of degeneration such as pyknotic nuclei, karyolysis, binucleated cells, Karyorrhexis and hyperchromatic nuclei. Immunohistochemical studies showed significant reduction in Ki-67 expression with a significant increase in P53 expression in diabetic group when compared with the control one. Conclusion: DM affects the oral epithelium in a way that affects its integrity and accordingly makes it more vulnerable to variable disease and infections.

[Mona A. Abd-Elmotelb. Morphometric, Histological and Immunohistochemical Study of Tongue Epithelium in Diabetic Rats. Life Sci J 2018;15(11):1-6]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 1. doi:10.7537/marslsj151118.01.

Key words: Diabetes mellitus, Tongue, Oral epithelium, Ki-67, P53

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Role of Bcl-2 Expression in the Diagnosis of Uterine Leiomyoma

Wageih S. Elnaghy¹, Abdel Khalek H.S.¹, M. O. Ramdan¹, Dareen Abd Elaziz Mohamed², Sarah A. Hamam³, Radwa Mahmoud Elsharaby³, Shereef Lotfy El Shwaikh⁴ and Ahmed Mahmoud El Khyat⁴

¹Medical Microbiology and Immunology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

²Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

³Clinical Pathology, Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

⁴Obstetrics and Gynaecology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

wighwigh535@gmail.com

Abstract: Bcl-2 (B-cell lymphoma/leukemia-2) is a protein that inhibits apoptosis. Uterine leiomyoma is a benign cancer in the smooth muscles of the uterus and affecting about 30% of women more than 35 years. The current work aimed to evaluates the techniques of both immunohistochemical and an enzyme-linked immunosorbant assay (ELISA) to measure Bcl-2 in the leiomyomatous tissue and in the healthy myometrium (control) and compares the data with that of Western Blot technique (WB). This study included 36 women attended Obstetric and Gynaecology Department, Tanta Faculty of Medicine, from August 2017 to February 2018. Twenty four were examined clinically and by ultrasound for detection of uterine fibroids which subsequently were confirmed by histopathological examination. Twelve patients were having normal myometrium free from fibroid but carrying other lesions. The myometrium obtained after surgery were examined at the Histopathology Department, Tanta Faculty of Medicine, where ELISA and Western blotting were done in the Medical Microbiology & Immunology Department, Tanta Faculty of Medicine. No significant variations were found among the control and study cases concerning ages, gravidity, abortions and parity. A highly significant variation in Bcl-2 status in the myometrium and the leiomyomtous tissues in the same group and similarly, amongst the control myometrium and leiomyomatous tissues. In addition, non-significant differences were reported amongst Bcl-2 contents either of the control myometrium and confirmed cases or in the proliferative and secretory endometrium. The same tissue lysates from 30 thirty-six women were analysed by both ELISA and WB methods. Merely 3 samples were less than 40U/mg by ELISA from the control group not contained Bcl-2 band. The remaining of the samples indicated to a clear Bcl-2 band, which vary in intensity depending on the level of Bcl-2. It is concluded that the high expression of Bcl-2 in leiomyoma comparative to that of normal myometrium might be considered as one of markers for detection of leiomyoma progression depending on the molecular bases.

[Wageih S. Elnaghy, Abdel Khalek H.S., M. O. Ramdan, Dareen Abd Elaziz Mohamed, Sarah A. Hamam, Radwa Mahmoud Elsharaby, Shereef Lotfy El Shwaikh and Ahmed Mahmoud El Khyat. Role of Bcl-2 Expression in the Diagnosis of Uterine Leiomyoma. Life Sci J 2018;15(11):7-12]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 2. doi:10.7537/marslsj151118.02.

Key words: W.B, western blot technique. ELISA Enzyme linked Imunosorbent assay.

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A Comparative Study of Pregnancy Outcome of Sequential Versus Day 3 and Day 5 Embryo Transfers

Ashraf Hamdy¹ and Osama Deif²

¹Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.

²Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

ashraf.hamdy@live.com

Abstract: Background: The recent improvement of sequential media has changed consideration upon the role of human blastocyst in ART because of its advantages but because of possible cancellation of embryo transfer when relying on blastocyst transfer only, sequential transfer on day 3 and day 5, was proposed. Objective: To know the pregnancy outcomes of sequential embryo transfer on day 3 and day 5, versus cleavage transfer on day 3 and blastocyst transfer on day 5. Methods: This was a prospective randomize trial in which 210 patients undergoing IVF/ICSI were included and divided into 3 groups, each group included 70 patients. Embryo transfer was performed in day 3 of first group, day 5 (blastocyst transfer) in the second group and sequential embryo transfer in day 3 and day 5 in the third group. Pregnancy outcomes of all the three groups were studied. Results: Equally implantation and clinical pregnancy rates were highly significant in the sequential group than at day 3 or at day 5 groups of embryo transfer. Conclusions: S equential transfer on day 3 and day 5 in patients with adequate number of retrieved oocytes is associated with a higher embryo implantation and clinical pregnancy rates and is advocated for women having an acceptable number of embryos of good quality.

[Ashraf Hamdy and Osama Deif. A Comparative Study of Pregnancy Outcome of Sequential Versus Day 3 and Day 5 Embryo Transfers. Life Sci J 2018;15(11):13-18]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 3. doi:10.7537/marslsj151118.03.

Keywords: Blastocyst transfer, consecutive transfer, sequential transfer, Implantation rate.

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A Hybrid-Based Harmony Search Algorithm for RNA Multiple Sequence Alignment

Mubarak S. Mohsen, Rosni Abdullah, Mohd. Adib Omar

School of Computer Sciences, Universiti Sains Malaysia, Penang, 11800, Malaysia

mobarak_seif@yahoo.com, rosni@cs.usm.my, adib@cs.usm.my

Abstract: Multiple sequence alignment (MSA) is an important topic in the field of computational molecular biology. Scalability, computational complexity as well as biological accuracy, are currently required for MSA methods. Finding an accurate alignment from primary sequences is computationally NP-hard problem. The aim of this study is to investigate and explore the capability of meta-heuristic technique known as harmony search algorithm (HS) to address MSA problem. This study introduces BHS-MSA, MHS-MSA, and HHS-MSA methods based on harmony search algorithm. Using a well-known benchmark (BRAliBase), the proposed method HHS-MSA showed better results compare to (BHS-MSA and MHS-MSA). HHS-MSA produced comparative results in terms of quality (Q) and total column (TC) and achieved good results in certain test groups especially alignments with large sequences.

[Mubarak. S. M., Rosni A., Adib O. A Hybrid-Based Harmony Search Algorithm for RNA Multiple Sequence Alignment. Life Sci J 2018;15(11):19-31]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 4. doi:10.7537/marslsj151118.04.

Keywords: RNA, Harmony search algorithm, Multiple sequence alignment, DCA, Conserved Blocks

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Incidence of Perioperative Stroke in Elderly Patients Undergoing Off-pump Versus On-pump Coronary Artery Bypass Grafting: A Systematic Review and Meta-analysis

Yu-Liang Miao^{a, b}, Wei-Wu Fang ^b, Yan Liu ^b, Lu Li ^c, Wei-Dong Mi^a

^a Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, China

^b Department of Anesthesiology and ^cDepartment of cardiothoracic surgery, PLA No. 306 Hospital, Beijing 100101, China

Tel: +86 10 66938151; Fax: +86 10 66938151; Email: weidm_pla@163.com

Abstract: Objective: To evaluate the incidence of perioperative stroke in elderly patients undergoing off- pump coronary artery bypass grafting and on-pump coronary artery bypass grafting using meta-analysis. Methods: Databases including Pub Med, EMbase, CNKI and Wan Fang Data were searched (1990 to 2012). Results: A total of 17 studies were included, involving 7257 patients including 2521 in the OPCAB group and 4754 in the CABG group. The results of meta-analysis showed that statistical difference in stroke incidence between the OPCABG and CABG. Conclusion: OPCAB may reduce incidence of perioperative stoke in elderly patients. However, it still needs to be confirmed by more multicenter, large-sample controlled trials in the future.

[Yu-Liang Miao, Wei-Wu Fang, Yan Liu, Lu Li, Wei-Dong Mi. Incidence of Perioperative Stroke in Elderly Patients Undergoing Off-pump Versus On-pump Coronary Artery Bypass Grafting: A Systematic Review and Meta-analysis. Life Sci J 2018;15(11):32-37]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 5. doi:10.7537/marslsj151118.05.

Key words: Coronary artery bypass grafting; Stroke; Elderly; meta-analysis

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Removal of Histidine Residue From zn- α₂- Glycoprotein by Carboxypeptidase Enzyme Using Spectrofluorimetry and Maldi-TOF-Mass Spectroscopy

Zain Ullah^1,2, Lindsay McDermott², Musa Kaleem Baloch¹, S. Veneeth²

¹Department of Chemistry, Gomal University, Dera Ismail Khan, KPK, Pakistan

²Diabetes and Nutritional Science Division, King’s College London, UK

 zain_kust@yahoo.com

Abstract: The present invention relates, in general, to methods developed of diagnosing and monitoring to binding with Zn-α₂-glycoprotein in order to designrational drugs. Zinc-alpha2-glycoprotein (ZAG) is a secreted protein that is present in most bodily fluids. It is interesting because of its ability to play many important functions in the human body, including fertilization and lipid mobilization. After the discovery of this molecule, during the last 5 decades, various studies have been documented on its structure and functions but still it is considered as a protein with an unknown function. Its expression is regulated by glucocorticoids. Due to its high sequence homology with lipid-mobilizing factor and high expression in cancer cachexia, it is considered as a novel adipokine. On the other hand, its X-ray crystal structure and folding structure is similar to MHC class I antigen-presenting molecule; hence ZAG may have a role in the expression of the immune response and providing defined binding-altered mutants for cellular signaling studies and potential medical application. Spectrofluorimetry and MALDI-TOF Mass Spectroscopy showed that ZAG binds DAUDA with Kdin the micromolar range. This study will examine removal of histidine residue from recombinant ZAG protein by enzymes through Spectrofluorimetry and MALDI-TOF Mass Spectroscopy.

[Zain Ullah, Lindsay McDermott, Musa Kaleem Baloch, S. Veneeth. Removal of Histidine Residue From zn- α₂- Glycoprotein by Carboxypeptidase Enzyme Using Spectrofluorimetry and Maldi-TOF-Mass Spectroscopy. Life Sci J 2018;15(11):38-44]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 6. doi:10.7537/marslsj151118.06.

Keywords: Zn-α₂-glycoprotein; Histidine; MALDI; Fluorescence; UV absorbance.

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Effect of Gamma-ray Radiation on Morphological Development of Orthosiphon stamineus (Cat Whisker)

Kamaludin A Rashid¹*, Mohd Izwan Jamaludin¹, Reza Farzinebrahimi², Arash Nezhadahmadi²*, Rosna Mat Taha², Nor Azlina Abd Aziz¹, Mahassan Mamat¹

^1. Centre for Foundation Studies of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia

^2. Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia

nezhadahmadi.arash@gmail.com, kamalrashid@um.edu.my

Abstract : In this study, the vegetative parts of Orthosiphon stamineus were exposed to gamma radiation with 3, 6, 9 and 12 minutes exposure time period by using gamma cell 220 Co-60 machines at 0.08344 Gy dosages to investigate the effect of gamma ray. After 7 weeks of gamma ray radiation, plant survival percentages, height of plants, number of leaves, chlorophyll and carotenoid content were recorded and calculated every week. Survival rates of gamma ray irradiated explants of Orthosiphon stamineus were changed dramatically. It was found that the height of plant and number of leaves per plant was decreased following irradiation. Gamma ray irradiation also inhibited chlorophyll and carotenoid content compared to non-irradiated plants which showed higher content of chlorophyll and carotenoid.

 [Kamaludin A Rashid, Mohd Izwan Jamaludin, Reza Farzinebrahimi, Arash Nezhadahmadi, Rosna Mat Taha, Nor Azlina Abd Aziz, Mahassan Mamat,. Effect of Gamma-ray Radiation on Morphological Development of Orthosiphon stamineus (Cat Whisker). Life Sci J 2018;15(11):45-50]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 7. doi:10.7537/marslsj151118.07.

Keywords: Gamma ray, Orthosiphon, Radiation

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Review on Biofilm Processes for Wastewater Treatment

Khaled Shahot, Azni Idris, Rozita Omar and Hamdan M. Yusoff

Department of Chemical and Environmental Engineering, Universiti Putra Malaysia, Serdang, Malaysia

Kmshahot@gmail.com

Abstract: This review paper discusses the application of biofilm as an alternative technology for the treatment of wastewater under various loading and operation conditions. In the past few years the biofilm technology has become more common and widely used in the world to meet the requirement for clean water sources of the world’s growing population. Besides, the conventional wastewater treatment plants like activated sludge process present some shortcomings such as not very flexible method (if there is sudden change in the character of sewage and the effluent of bad quality is obtained), so better system is urgently needed to provide additional capacity with the least possible cost and to meet the standard effluent by the local authorities. The increased incoming flow of wastewater to the treatment plants and organic loading always demand for additional treatment capacity. Fundamental research into biofilm is presented in this paper in sections that discuss the use of biofilm whereby a comparison between suspended and fixed film, old and new biofilm are made. Besides, bed types namely moving bed, fixed bed and floating bed, un-submerged fixed film systems of trickling filters and rotating biological contactors are explained. Nutrients removal of nitrogen and phosphorus and nano technology application in biofilm are also explained. Results from investigations of different applications carried out at the laboratory and pilot scales are also discussed.

[Khaled Shahot, Azni Idris, Rozita Omar and Hamdan M. Yusoff. Review on Biofilm Processes for Wastewater Treatment. Life Sci J 2018;15(11):51-64]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 8. doi:10.7537/marslsj151118.08.

Keywords: biofilm, wastewater treatment, trickling filter, rotating biological contactors, nutrients removal.

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Occupational exposure to anesthetic gases and risk of spontaneous abortion

Somaye behnamipour¹, Alireza kouhpaie², Yalda Arast^3¯, Samane Sabet Birjandi⁴, Alireza Mashkoori⁵, Mohsen Mahdineya⁶

¹ Msc. of Analytical Chemistry, Research center of Environmental Pollutants, Qom University of Medical Sciences

² Assistant Professor of Occupational Health Engineering, Toxicology Research Center, Qom University of Medical Sciences, Qom, Iran

^{3 ¯} Instructor of Toxicology, Toxicology Research Center, Qom University of Medical Sciences, Qom, Iran

⁴ Lecturer of Midwifery Islamic Azad University branch of Birjand

⁵ Instructor of Occupational Hygiene, Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran

⁶ Msc of Occupational Hygiene, Department of Occupational Health Engineering, Qom University of Medical Sciences, Qom, Iran

Abstract: Objective: Nowadays, some studies indicate the adverse effects of exposure to chemicals such therapeutic agents. We investigated self-reported occupational exposure to anesthetic gases and the risk of spontaneous abortion in women hospital staff in Qom. Methods: This study is a case control study which has carried out in 2013 in three hospitals of Qom University of Medical Sciences. During the study, married women who were working in the operating room as technicians and nurses ( exposure group) compared with married women who were working in CCU, ICU and emergency as nurses (non exposure group). Rate of spontaneous exposure were assessed in both groups. Collected data were analyzed by SPSS software. Results: in this study pregnancy outcome and occupational exposures were collected retrospectively 143 participants of women hospital staff. In this study the rate of abortion in exposure group was 15.6% (n=11) and in non exposure group was 13.52% (n=10). Thus significant relationship between exposure to anesthetic gases and spontaneous abortion wasn’t seen. Conclusion: these data suggest that focus on review of the status of occupational exposure of workers can be helpful in improving the reproductive of female workers. Though our study supports the idea that the use of engineering controls such Scavenging can reduce the concentration of anesthetic gases to prevent their possible effects on pregnancy and risk of spontaneous abortion.

[Somaye behnamipour, Alireza kouhpaie, Yalda Arast Samane Sabet Birjandi, Alireza Mashkoori, Mohsen Mahdineya. Occupational exposure to anesthetic gases and risk of spontaneous abortion. Life Sci J 2018;15(11):65-68]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 9. doi:10.7537/marslsj151118.09.

Keywords: anesthetic gases, occupational exposure, abortion

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A Suggested Model for Evaluating MOOC Platforms According to Educational and Technical Standards

Rania Y. Saleem

Educational Technology Department, Jeddah University, Jeddah, Saudi Arabia

Email: rsaleem@uj.edu.sa, raniasaleem@gmail.com

Abstract: Background: To provide more opportunities for learners and to achieve greater effectiveness in the educational process, it is necessary to utilize e-learning platforms to support education. However, it is important to monitor the problems of these platforms and evaluate their effectiveness in improving educational performance in the light of approved educational and technical standards. Objective: The aim of this study is to provide a suggested model that can be used to evaluate open e-learning platforms according to specific educational and technical standards. Methods: Relevant literature on the topic were reviewed and faculty members were consulted. Results: Considering literature review and the jury members’ response analysis, the researcher set a suggested model consist of two-domain List (educational & technical standards); total of 6 standards, 24 sub-standards and 46 indicators. The educational domain composed of 3 standards, 8 sub-standards and 16 indicators. The technical domain consists of 3 standards, 16 sub-standards and 30 indicators. This list has been judged by 30faculty members from 6 universities. The agreement percentage was calculated according to "Cooper" equation, and the agreement percentage of educational standards was (90.63%) and of technical standards was (86.22%), while the agreement percentage of the Standard List was (87.75%). All percentages are more than 80%. Conclusion: It is aspired that the model items will serve as a guide in the MOOC platforms evaluation.

[Rania Y. Saleem. A Suggested Model for Evaluating MOOC Platforms According to Educational and Technical Standards. Life Sci J 2018;15(11):69-79]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 10. doi:10.7537/marslsj151118.10.

Keywords: MOOC Platforms, MOOC Evaluation, Standard List, Educational Standards, Technical Standards.

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Comparison between Nanokaolin and Nanocupper Oxide for removal of Direct Blue 3B from Water, in vitro

Sabah S. Ibrahim and Belal N.A. Mahran

Chemistry Department, Central Lab for Environmental Quality Monitoring, National Water Research Center, Delta Barrage, Egypt

sbah.ibrahim@yahoo.com

Abstract: Increasing concentrations of azo-dyes such as direct blue 3B in surface and groundwater are a chief environmental distress in current years. In this study, nanokaolin and nanocupper oxide were used as a trial for removal of direct blue3B residue from watery solution. Methods, nanoKaolin and nanocupper oxide were characterized by X Ray Diffrication (XRD), surface area and Transsion Electronic Microscope (TEM) methods. impact of different factors like, adsorbent dosage, interaction time, and preliminary level of direct blue 3B and temperature on adsorption of direct blue 3B on nanokaolin and nanocupper oxide was investigated. The results investigated that the greatest state for elimination of direct blue 3B was revealed at 90 min contact time and 1g/L adsorbent dosage. the elimination of direct blue 3B diminished with the rise of initial level. Langmuir and Freundlich isotherm models were used for the equilibrium data. Kinetic study applied pesudo first and second direction. Results pointed to the possible role of nanokaolin and nanocupper oxide for elimination of direct blue 3B from aqueous solutions.

[Sabah S. Ibrahim and Belal N.A. Mahran. Comparison between Nanokaolin and Nanocupper Oxide for removal of Direct Blue 3B from Water, in vitro. Life Sci J 2018;15(11):80-93]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 11. doi:10.7537/marslsj151118.11.

Keywords: Comparison; Nanokaolin; Nanocupper; Oxide; Blue 3B; Water; in vitro

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Bee propolis, Luperon depot 3.75mg treatment of uterine fibroid. A randomized, controlled clinical trial

Ali Farid M. Ali¹, Laila Farid, ² and Samir Shaker³

¹Consultant Obstetrics and Gynecology Heliopolis Hospital, Cairo, Egypt.

²Consultant Obstetrics and Gynecology, Cairo Medical Centre, Cairo, Egypt.

³Consultant Clinical Pathology, Heliopolis, Cairo, Egypt.

elshayb1950@yahoo.com

Abstract: Introduction: Uterine fibroid is the most common benign tumors of the uterus, hysterectomy is the definitive treatment of symptomatic fibroid. Medical treatment of uterine fibroids include androgens, antiprogestogens, raloxfene and the most common used treatment GnRH agonist, we introduced for the first time in the literature Bee propolis in the treatment of uterine fibroid. Objective: To compare the efficacy and safety of Bee propolis vs. GnRHagonist in the treatment of uterine fibroid. Design: It is a randomized controlled clinical trail. Patients and methods: A total of 30 patients with a single fibroid measuring ≥8cm were randomized into two groups group 1 treatment with Bee propolis and group II with GnRHa. (Luprone depot 3.75). Bee propolis was given in a tablet form 500mg three time daily for 12weeks. Main outcome measures: Measurement of fibroid volume, uterine volume, Hb concentration and hot flashes. Results: Statically significant decrease in the fibroid and uterine volume in both groups but more in the group 1 (p<0.01) statistically significant increase in Hb concentration in the two groups but more in the group I p< 0.01). No hot flashes recorded in group I P < 0.0001), hot flashes recorded in all group II. Conclusion: Bee propolis is a new line treatment of uterine fibroid with more reduction in fibroid volume, uterine volume and increase in the Hb concentration more than GnRHa no reported hot flashes.

[Ali Farid M. Ali, Laila Farid, and Samir Shaker. Bee propolis, Luperon depot 3.75mg treatment of uterine fibroid. A randomized, controlled clinical trial. Life Sci J 2018;15(11):94-97]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 12. doi:10.7537/marslsj151118.12.

Keyword: Uterine fibroid, Bee propolis, GnRHa, hot flashes Luperon depot 3.75

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Bee Propolis Treatment of Uterine Myoma A New Modality

Ali Farid M. Ali¹, Laila Farid,² and Samir Shaker³

¹Consultant Obstetrics and Gynecology Heliopolis Hospital, Cairo, Egypt.

²Consultant Obstetrics and Gynecology, Cairo Medical Centre, Cairo, Egypt.

³Consultant Clinical Pathology, Heliopolis, Cairo, Egypt.

elshayb1950@yahoo.com

Abstract: Introduction: Uterine myomas are the most common benign tumors of the uterus, hysterectomy is the definitive treatment of symptomatic uterine myomas. Medical treatment of uterine myomas include androgens, antiprogestogens, reloxifene and the most common used treatment GnRH agonist, we introduced for the first time in the literature Bee propolis in the treatment of uterine myoma. Objective: To test the efficacy and safety of Bee Propolis in the treatment of uterine myoma. Patients & Methods: A total of 20 with a single myoma measuring ≥ 8cm were enrolled in the study. Bee propolis was taken in the tablet form 500mg three times daily for 12 weeks, measuring Hb concentration before and after the treatment. Main outcome measuring: Measurement of myoma volume, uterine volume, Hb concentration. Result: Statistically significant decrease in the myoma and uterine volume after treatment. (P<0.01) statistically significant increase in Hb concentration. (P < 0.01). Conclusion: We introduced bee propolis as a novel medical treatment of fibrod with no adverse effect.

[Ali Farid M. Ali, Laila Farid, and Samir Shaker. Bee Propolis Treatment of Uterine Myoma A New Modality. Life Sci J 2018;15(11):98-100]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 13. doi:10.7537/marslsj151118.13.

Keyword: Uterine myoma, Bee propolis, GnRH agonist, Medical Treatment

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