Welcome to send your manuscript to: lifesciencej@gmail.com

No.

Titles / Authors /Abstracts

Full Text

No.

1

Soluble carcinoembryonic antigen cell adhesion molecule 1,6 and 8 in acute myeloid leukemia: their relation to survival and prognosis

Amal Zaghloul^{1 & 2}, Heba Kamal^{3 & 4}, Manar M. Ismail^{3 & 5}, Shirin H. Teama^{2 & 6}, Nahla AB. Abdulateef ^{5 & 7}

¹Hematology and Immunology Department, Faculty of Medicine, Umm Al Qura University, KSA,

²Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Egypt,

³ Laboratory Medicine Department, Faculty of Applied Medical Science, Umm Al Qura University, KSA,

⁴Biochemistry Department, Faculty of Medicine, Mansoura University, Egypt.

⁵Clinical Pathology Department, National Cancer Institute, Cairo University, Egypt,

⁶ Clinical Chemistry Department, King Abd Alaziz Hospital, Makkah, KSA.

⁷ Laboratory and Blood Bank Department, KAMC, Makkah, KSA.

Email: amalzaghloul1@hotmail.com; amalzaghloul66@hotmail.com

Abstract: Background: The carcinoembryonic antigen cell adhesion molecules (CEACAM) play important roles in cell adhesion as well as cancer cell invasion and metastasis. Objectives: to study the soluble CEACAM 1,6 and 8 in acute myeloid leukemia (AML) and to determine if they had an impact on the survival and prognosis. Methods: 102 subjects were included. They were 53 with AML and 49 healthy persons. All were subjected to the measurement of soluble CEACAM 1,6 and 8 by ELISA. The patients were divided into the high and low group by using median of each parameter in patients as a cut off value. Results. Significant increase of sCEACAM1,6 and 8 was found in their high group when compared to the control group. No significant difference was found in the low group of both sCEACAM1 and 6 when compared to the control. In contrast, a significant increase of sCEACAM8 was found. There were significantly positive and negative correlation of the high sCEACAM1 with lactic dehydrogenase and each of the surface CD66a, sCEACAM6 and 8 respectively. Significant positive correlations were found between sCEACAM6 and 8. There was a Significant increase of the relapse-free survival (RFS) in the highest group of sCEACAM6. Also, it was associated with increased overall survival (OS) 6.2 times when compared to the low group. Soluble CEACAM8 had a significant good impact on induction remission. Conclusion: The high group of sCEACAM6 and sCEACAM8 are independent good prognostic factors for overall survival and induction remission. sCEACAM1 is a poor prognostic factor.

[Amal Zaghloul, Heba Kamal, Manar M. Ismail, Shirin H. Teama, Nahla AB. Abdulateef. Soluble carcinoembryonic antigen cell adhesion molecule 1,6 and 8 in acute myeloid leukemia: their relation to survival and prognosis. Life Sci J 2018;15(4):1-11]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 1. doi:10.7537/marslsj150418.01.

Keywords: CEACAM1, 6,8, AML

Full Text

1

2

The effect of percentage of immature oocytes at the time of oocyte retrieval on ICSI outcomes

Mofeed Fawzy Mohamed, Abd El-Moneim Mohamed Zakria, and Mohamed Ebrahim Hefnawy

Department of Obstetrics & Gynecology Department, Faculty of Medicine, AL-Azhar University, Egypt

E-mail: dr.mofeed.fawzy@hotmail.com

Abstract: Purpose: The goal wastoassesstheeffect of thequantity of immature oocytes at the time of oocyte retrieval on (ICSI) outcomes. Patients and methods: A prospective selective clinical study was performed in assisted reproduction unit (Hawa Hospital), Atotalof100ICSIcycleswereincluded, Patientswere divided into two groups; (GroupⅠ) included patients with the percentage of mature (M2) oocytesmorethan 50%, and (groupⅡ) includedpatientswiththerateof matureoocytes (M2) lessthan 50% of the total retrievedoocytes. Results: There were significant differences for Fertilization rate between both groups; it was 72.21% for (group Ⅰ) and 49.07 % for (group Ⅱ) (P = 0.049). Implantation rate appeared to be highly significant; the implantation rate in (group Ⅰ) was 33.37 %, versus 17.79 % in (group Ⅱ) (P = 0.028). There was a statistical difference between (group Ⅰ) and (group Ⅱ) as regards embryo grading (D3). Also, the rates of clinical pregnancy were significant between groups; 47% of (group Ⅰ) and 33% of (group Ⅱ) patients; (P = 0.04). Conclusion: In cases with few retrieved immature oocytes, rates of fertilization may increase.

[Mofeed Fawzy Mohamed, Abd El-Moneim Mohamed Zakria, and Mohamed Ebrahim Hefnawy. The effect of percentage of immature oocytes at the time of oocyte retrieval on ICSI outcomes. Life Sci J 2018;15(4):12-16]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 2. doi:10.7537/marslsj150418.02.

Keywords: immature oocytes, intracytoplasmic sperm injection.

Full Text

2

3

Using of Glass Fiber Reinforced Polymer Bars as Reinforcement for Reinforced Concrete Beams Exposed to Fire

Ahmed Goma Asran¹, Hatem Hamdy Ghith², Mohamed Nooman³, and Shady Khairy ⁴

¹ Prof. Reinforced Concrete Dept., Faculty of Engineering, Al-Azhar University, Cairo, Egypt.

² Prof. Reinforced Concrete Dept., Building National Research Center, and Cairo, Egypt.

³ Ass. Prof. Civil Engineering Dept., Faculty of Engineering, Al-Azhar University, Cairo, Egypt.

⁴Teaching Ass., Civil Engineering Dept., Higher Technological Institute 10^th of Ramdan City, Egypt.

shady_khairy2005@hotmail.com

Abstract: In recent years, some attempts have been performed to extend general design rules reported in the codes for steel reinforced concrete to Fiber Reinforced Polymer (FRP) materials; this is the case of relationships adopted in the evaluation of the effect of high degrees of temperature on FRP bars comparison with steel bars. However, such relationships seem to be inappropriate for FRP reinforcing bars: in fact, experimental test results have shown high resistance to tire carbon (C330-10%) bars to change the high temperatures and high outweigh on GFRP compared to steel reinforcement and that bond behavior of C.GFRP (C330-10%) bars is different from that observed in case of deformed GFRP and deformed steel. As a consequence, a new procedure for the evaluation to change the high temperatures based on an analytical approach is needed in order to directly account for the actual values as obtained by experimental tests on mixing different resin types with GFRP reinforcing bars. During this research contribution, an experimental study of C.GFRP (C330-10%) bar as a resistance bar for high degrees of temperature and concrete bond test is carried out and presented to investigate the bond stress behavior for normal concrete, and study feasibility of using glass fiber reinforced polymer bars resistance high degrees of temperature as reinforcement for reinforced concrete beams. The tested specimens included eight concrete beams with 1800mm length, 100mm width and 200mm height.

[Ahmed Goma Asran, Hatem Hamdy Ghith, Mohamed Nooman, and Shady Khairy. Using of Glass Fiber Reinforced Polymer Bars as Reinforcement for Reinforced Concrete Beams Exposed to Fire. Life Sci J 2018;15(4):17-30]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 3. doi:10.7537/marslsj150418.03.

Keywords: fire, high temperature, C.GFRP (C300-10%), composite matrix,R C beams, Bond, Tension stiffening

Full Text

3

4

Experimental Studies on Effects of Alkaline Solution Type on Behavior of Zeolite & Red-Mud Based Geopolymer Mortar

El-Kholy, S.A.¹, Hasan, H. El Deen², Asran, A. Gomaa ³, Abd Al-Kader, A. Al Sayed ⁴

¹Prof, Civil Engineering Department, Al Azhar University, Cairo, Egypt,

²Civil Engineering Department, Banha University, Shoubra, Egypt,

³Prof, Civil Engineering Department, Al Azhar University, Cairo, Egypt,

⁴ Teaching Ass., Civil Engineering Department, Higher Technological Institute, 10th of Ramadan City, Egypt,

ahmed_abdelkader_86@hotmail.com

Abstract: This paper presents an experimental study on the effective usage of Red-Mud (Aluminum slag) and Zeolite in geopolymer mortar. Potassium and Sodium based alkaline activators with sodium Meta silicate (Na₂SiO₃) were used for different mix proportions. The parameters in this study were the NaOH or KOH solution molarity and the Na₂SiO₃/NaOH, KOH ratio. Three NaOH or KOH concentrations (8, 12, and 16 molars) were inspected. The results showed that the studied parameters significantly affected the properties of the produced geopolymer mortars. Pozzolanic activity, Workability, setting time and accelerated mortar bar test (AMBT) were investigated and presented.

[El-Kholy, S.A., Hasan, H. El Deen, Asran, A. Gomaa, Abd Al-Kader, A. Al Sayed. Experimental Studies on Effects of Alkaline Solution Type on Behavior of Zeolite & Red-Mud Based Geopolymer Mortar. Life Sci J 2018;15(4):31-39]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 4. doi:10.7537/marslsj150418.04.

Keywords: Zeolite, Red Mud (Aluminum slag), Pozzolanic activity, Geopolymer mortar, Alkaline-Activators; Alkali-aggregate reaction.

Full Text

4

5

Antifibrotic Mechanisms of Resveratrol in Modulating Liver Fibrogenesis

Suzan Bakr Abdu and Fatima Motlag Al-Bogami

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80200, Jeddah, 21589 Saudi Arabia

Email address: sabdu@kau.edu.sa; suzanabdu3@gmail.com

Abstract: Liver fibrosis results from chronic inflammation to the liver with accumulation of extracellular matrix proteins, eventually leads to cirrhosis. Recently, natural supplements therapy has grown widely. Resveratrol is a polyphenol derived mainly from grapes considered to have a broad spectrum of pharmaceutical activities. The present study investigated the histological incidents of liver fibrogenesis and the cellular mechanisms by which resveratrol prevented and modulated liver fibrosis. Six groups of rats were used. One group served as control. Another was given resveratrol by oral gavage (20 mg/kg body weight/day). The third was injected intraperitoneally with dimethylnitrosamine (10mg/kg 3days/week) to induce liver fibrosis. The fourth was pre-treated with resveratrol then dimethylnitrosamine for 3 weeks. After cessation of dimethylnitrosamine, two subgroups from dimethylnitrosamine intoxicated group were daily post-treated with resveratrol (20mg/kg and 40mg/kg) for a week. Results revealed that resveratrol remarkably recovered body and liver weight and alleviated the histopathological alterations of hepatic fibrosis in time and dose-dependent manner. In conclusion, resveratrol may have employed two mechanisms in modulating liver fibrosis; arrested fibrosis progression through blocking hepatic stellate cell activation and/or reversion as well as stimulated resolution via triggered apoptosis. Resveratrol can be used as antifibrotic and reversing agent in liver disease therapy.

[Suzan Bakr Abdu and Fatima Motlag Al-Bogami. Antifibrotic Mechanisms of Resveratrol in Modulating Liver Fibrogenesis. Life Sci J 2018;15(4):40-51]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 5. doi:10.7537/marslsj150418.05.

Key words: Resveratrol, Hepatic fibrosis, Prevention, hepatic stellate cell, Myofibroblast, Apoptosis

Full Text

5

6

Quercetin and resveratrol effectson peptic ulcer in experimental rats

Samaa S. Elsoadaa1, El-SayedH. Bakr1,2, Haifaa H. Hijazi1 and SamehM. Baz3,4

1Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA.
2Nutrition and Food Science Department, Facultyof Home Economics, Minufiya University, Egypt.
3Lab Medicine Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA.
4Clinical Pathology Department, Cairo University Hospital, Cairo, Egypt.
sayedhamed20007@hotmail.com

Abstract: Generally, peptic ulcer disease is known as an inflammation or excavations in the mucous membrane and tissues of the gastrointestinal tract. Breakdown of the mucus membrane normally lining the esophagus, stomach and duodenum due to the action of gastric hydrochloric acid and pepsin usually leads to peptic ulcer lesions. Many synthetic anti-ulcer drugs (e.g., misoprostol) used for preventing or treating non-steroidal anti-inflammatory drugs (NSAIDs) made gastric lesions. On the other hand, such therapies can induce unpleasant side-effects like itching, skin rash, diarrhea, and dizziness. This study was designated to clear out the effect of quercetin, resveratrol and mixture of them on curing aspirin induced ulcers in male rats. Thirty-two male albino rats (20010g b.wt.) were used and divided into 8 groups (n= 4 rats), one group was kept as control -ve group while rest of groups (7), were given orally aspirin (200mg/kg b.wt.) only (control +ve), while the rest of groups were treated orally with quercetin, resveratrol and mixture of them at two doses of 25 and 50 mg/kg b.wt., for each group for seven days. These parameteres were determined, gastric ulcer length, gastric juice volume, pH, total acidity and histopathological picture.It is concluded that oral treatment with both l quercetin and resveratrol at two dose levels ( 25 and 50 mg/kg b.wt.) shown significant reduction of gastric ulcerarea, total acidity, volume of gastric juice and histopathological changes. Moreover, quercetin extracts and resveratrol increased pH value of gastric juice. The rats administered with mixture of (quercetin + resveratrol) at dose of 50 mg/kg b.wt., showed the highest significant decrease in the gastric ulcer compared to all treated groups. Quercetin and resveratrol could be contribute in healing of gastric ulcer disease.
[Samaa S. Elsoadaa, El-Sayed H. Bakr, Haifaa H. Hijazi and Sameh M. Baz. Quercetin and resveratrol effectson peptic ulcer in experimental rats. Life Sci J 2018;15(4):52-59]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 6. doi:10.7537/marslsj150418.06.

Key words: Quercetin, resveratrol, peptic ulcer and histopathological changes

Full Text

6

7

hort-term outcome of laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric plication (LGP) in morbidly obese patients

Islam M. Ibrahim MD., Abd Elrahman Metwalli MD and Tamer Rushdy MD.

General Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

dr_moh2003@yahoo.com

Abstract: Background: Exercise, diet, and medications are not usually enough in morbidly obese patients to provide satisfactory and durable weight loss. Bariatric surgery is the best modality for weight loss and for resolving the associated comorbidities. Objective: To compare short-term outcome of LSG and LGP for treatment of morbid obesity. Patients and methods: Thirty patients presented for the study during the duration between May 2015 and August 2017. The patients were randomly classified into two equal groups: group A subjected to LSG and group B had LGP. All patients were subjected to preoperative assessment (history taking, physical examination, laboratory investigations, imaging studies, and cardiopulmonary assessment), upper GIT endoscopy or Barium meal, and quality of life assessment. Patient education and supervised dietary instructions were provided. All patients were informed about the advantages and disadvantages of two procedures and consented to be included in this randomized study. The written consents were signed by patients for the procedure to be performed for them. Patients were followed up for postoperative complications and overall outcome. Results: No major complications were observed in the early postoperative period. Two patients (one in each group) developed postoperatively symptomatic cholelithiasis. Three patients presented with mild stenosis symptoms (intermittent vomiting and intolerance to solid food), two patients were from group A and one from group B. There was no statistically significant difference between the mean preoperative weights in both groups. After one month, three months and six months, both groups experienced almost the same amount of weight loss. On the contrary, after 12 months follow up, group A demonstrated a greater weight loss. Percentage of excess weight loss was significantly higher among group A compared to group B. Similarly, percentage of excess weight loss (%EWL) was significantly higher among group A compared to group B after one month follow up. All patients had adequate weight loss except for one patient in group B. Quality of life was assessed at the end of follow up period. All patients had a good or very good outcome, reflecting the overall level of satisfaction of patients. 12 patients had a good outcome in group A compared to 10 in group B; while three patients in group A had a very good outcome compared to two in group B; and the difference was statistically non-significant. Conclusion: Both laparoscopic sleeve gastrectomy and laparoscopic greater curvature plication had a reasonable outcome on morbid obesity management, with preference of laparoscopic sleeve gastrectomy after 12 months postoperatively in the degree of weight loss and overall complications rate.

[Islam M. Ibrahim, Abd Elrahman Metwalli and Tamer Rushdy. Short-term outcome of laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric plication (LGP) in morbidly obese patients. Life Sci J 2018;15(4):60-67]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 7. doi:10.7537/marslsj150418.07.

Keywords: Obesity, bariatric surgery, laparoscopic sleeve gastrectomy, greater curvature plication.

Full Text

7

8

Developed Combination System of Desalination plant driven by Renewable Energy

Adel. Naser¹, M. Halawa² and M. Salah Mansour¹

¹Higher Technological Institute, Tenth of Ramadan city, Egypt.

²Mech. Department, Faculty of Engineering, Al Azhar University, Cairo, Egypt.

abosalah86@yahoo.com

Abstract: The greatest danger of the world at the present is the scarcity of water, resulting from drought and increased population. To overcome this problem, seawater desalination techniques should be focused on. On the other hand, it is important to provide a source of energy to extract fresh water from desalination plants. Since conventional energy is exhausted, expensive and polluted to the environment, it is necessary to turn to renewable energy as an alternative energy source in remote areas. The appropriate matching between renewable energy and seawater desalination systems is designed in this study according to special and relative considerations factors. The scope of the present work is to design Reverse Osmosis (RO) desalination plant driven by photovoltaic (PV) solar arrays. The design is constructed where developing and examining different parameters affecting the performance of the present combination system. The salt concentration and theflowrate of the supply water was found to have important effect on the permeate flux, permeate concentration, salt rejection percent, recovery percent and specific power consumption. A comparison was made between the present experimental results and a corresponding results of previous work under nearly operating condition. The agreement comparison is fairly good. In the present modification, the cooling medium suppling the photovoltaic plates is the brine water out from the desalination RO plant without the need for additional power for pumping cooling water. The cooling PV panels make an increase in the following: output generated volt, output current, output power, permeate flow rate, efficiency percentage, recovery percent and power ratio. The results is represented for two values of the brine water pressure namely 3.9 and 2.9 bar. The increase of the output power has a mean value of 4.5 % when applying the two values of present brine pressure. It can be noticed that the mean value of the gain in solar efficiency is about 22 % for brine pressure of 2.9 bar while the corresponding gain in solar efficiency is 16.8 % for brine pressure of 3.9 bar. According to decreasing of brine water pressure from 3.9 bar to 2.9 bar, this causes an increase in the permeate flow rate with amean value of 33.5 %.

 [Adel. Naser, M. Halawa and M. Salah Mansour. Developed Combination System of Desalination plant driven by Renewable Energy. Life Sci J 2018;15(4):68-78]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 8. doi:10.7537/marslsj150418.08.

Key words: Desalination Technique, Reverse Osmosis (RO), Renewable Energy (RE), Photovoltaic Cells (PV), cooling Photovoltaic panels, Energy management. Cooling Technique, Electrical Efficiency.

Full Text

8

9

Rule of dietary activated wood charcoal on the growth and biochemical composition of Gilthead Seabream (Sparus aurata) reared under different stocking densities

Fady R. Michael*¹ and Amr M. Helal²

¹Fish Nutrition Laboratory, Aquaculture Division, National Institute of Oceanography and Fisheries (NIOF), Egypt.

²Fish Rearing Laboratory, Aquaculture Division, National Institute of Oceanography and Fisheries (NIOF), Egypt.

* mfr_m@yahoo.com

Abstract: A 60-days’ two-way factorial design study was performed to evaluate the role of dietary activated wood charcoal (AWC) at various fish rearing densities on growth performance, body composition, and water quality of Gilthead Seabream (Sparus aurata) fingerlings. Two levels of AWC (20 and 40 g kg^-1) were added to the control diet (T1; 0 g kg^-1 AWC) and fed to Gilthead Seabream [initial weight (IW) of 0.5±0.1 g] at three different density levels (D1; 20, D2; 40 and D3; 60 fish m^-3). At the end of the experiment, survival (S), fish weight gain (WG), specific growth rate (SGR), feed conversion ratio (FCR), protein efficiency ratio (PER), and energy retention (ER) of the fish groups fed 20 and 40 g kg^-1 (T2 and T3 AWC) in diet were significantly (P<0.05) better compared to the control fish group at all density levels (D1, D2 and D3). Moreover, some proximate composition such as crude protein (CP) of the fish groups fed on 20 and 40 g kg^-1 AWC diets at different density levels showed higher values (P<0.05) than those of control fish groups (T1; 0 g kg^-1 AWC) at the three density levels (D1, D2 and D3 respectively). These data were powered by the data of the water quality that showed significant (P<0.05) enhancement in both dissolved oxygen and ammonia concentrations by the increment in dietary charcoal levels even at higher density levels (D2 and D3). The above-mentioned parameters’ data suggested that 40 g kg^-1 dietary AWC can be considered as a suitable level to maintain optimal growth of Gilthead Seabream juveniles especially at high density levels (D2 and D3) as well as to enhance water quality of the rearing tanks.

[Fady R. Michael and Amr M. Helal. Rule of dietary activated wood charcoal on the growth and biochemical composition of Gilthead Seabream (Sparus aurata) reared under different stocking densities. Life Sci J 2018;15(4):79-86]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 9. doi:10.7537/marslsj150418.09.

Key Words: Gilthead Seabream, Charcoal, Nutrition, Growth, Proximate composition, stocking densities.

Full Text

9

10

Mamdouh A. Kenawi

Assistant Professor, Civil Engineering Department, Sohag University, Sohag, Egypt

mkenawi2@yahoo.com

Abstract: The response of pile, subjected to axial (vertical) and lateral (horizontal) loads, is presented in this paper. PLAXIS 2D finite element software version 8.2 is used in this analysis. The pile is simulated as beam element of linear elastic properties. The Hardening soil model under drained condition was employed to simulate the soil stress-strain behavior. A horizontal force of 93.75, 187.5, and 375 kN is applied to the top, middle, and bottom of the pile which is embedded in loose sand, while maintaining 375 kN as axial load on the pile. Bending moment and lateral displacements along the pile length is explored in this paper. The effect of lateral force position, lateral force value, and axial load value on the pile response was studied. Results revealed that the distribution of bending moment and lateral displacement along the pile length is affect considerably by position and value of lateral load. However, the effect of vertical force value on pile response is not significant.

[Mamdouh A. Kenawi. Response of single pile under axial and lateral loads. Life Sci J 2018;15(4):87-91]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 10. doi:10.7537/marslsj150418.10.

Keywords, Index Terms: Pile-soil interaction, Axial loads, Lateral loads, Finite element analysis.

Full Text

10

11

LigaSure hemorrhoidectomy compared with stapled hemorrhoidopexy for management of grade III and IV hemorrhoids: A prospective randomized study.

Islam M. Ibrahim MD, Abd Elrahman Metwalli MD, Ashraf Goda MD

 General Surgery department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

ieslam4@yahoo.com

ABSTRACT: Background: Conventional hemorrhoidectomy often associated with post-operative complications, like pain, bleeding, anal stenosis, and incontinence, which can cause delayed convalescence. The Ligasure Vessel Sealing System (LVSS) enables us to do a bloodless hemorrhoidectomy with decreased pain postoperatively and rapid healing. Pain suspected to be low in stapled hemorrhoidopexy as the staple line is positioned above the dentate line and there is no external wound. Objective: To compare the efficacy and outcome of two surgical methods LigaSure versus stapler in the treatment of hemorrhoids. Patients & Methods: A prospective randomized study was done in the General Surgery department, Zagazig University hospital during the period from May 2016 till October 2017. Patients underwent surgical excision of hemorrhoids grade III or grade IV. They were divided into two groups: group (A) managed by Ligasure hemorrhoidectomy and group (B) managed by Stapled hemorrhoidopexy. Postoperative complications and Pain levels scoring were analyzed. Results: Group (A) had less operative time and recurrent prolapse while postoperative pain in Group (B) was statistically significantly lower with less analgesic requirement. As regarding other postoperative complications. The difference was not statistically significant between both groups. Conclusion: This study demonstratedthat Ligasure hemorrhoidectomy and stapled hemorrhoidopexy have good results, with a short operative time and few side effects in the treatment of hemorrhoids grade III and IV. Stapled hemorrhoidopexy offers much less pain but more recurrent prolapsed. Also we recommend a larger controlled study to prove recurrence of postoperative hemorrhoidalprolapse after treatment of hemorrhoids grade III and IV by LigaSure or stapler.

[Islam M. Ibrahim, Abd Elrahman Metwalli, Ashraf Goda. LigaSure hemorrhoidectomy compared with stapled hemorrhoidopexy for management of grade III and IV hemorrhoids: A prospective randomized study. Life Sci J 2018;15(4):92-99]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 11. doi:10.7537/marslsj150418.11.

Keywords: Hemorrhoids, Ligasure hemorrhoidectomy, Stapled hemorrhoidopexy.

Full Text

11